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Details on Person VEGFR-2 binds VEGF-A, -C, -D, and -E homodimers. VEGFR-2 is ...
| Class:Id | Summation:195572 |
|---|---|
| _displayName | VEGFR-2 binds VEGF-A, -C, -D, and -E homodimers. VEGFR-2 is ... |
| _timestamp | 2007-04-12 14:09:11 |
| created | [InstanceEdit:195566] Gopinathrao, G, 2007-04-09 01:56:10 |
| literatureReference | [LiteratureReference:195439] Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis [LiteratureReference:195436] Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis [LiteratureReference:195479] Signal transduction via vascular endothelial growth factor (VEGF) receptors and their roles in atherogenesis |
| modified | [InstanceEdit:195642] Gopinathrao, G, 2007-04-11 20:35:02 [InstanceEdit:195650] D'Eustachio, P, 2007-04-12 14:09:14 |
| text | VEGFR-2 binds VEGF-A, -C, -D, and -E homodimers. VEGFR-2 is the primary mediator of the physiological effects of VEGF-A in angiogenesis, including microvascular permeability, endothelial cell proliferation, invasion, migration, and survival. In endothelial cells, these effects are mediated via activation of a phospholipase gamma-protein kinase C-Raf-MAPK signaling pathway for proliferation and PI3K and focal adhesion kinase for survival and migration. VEGFR-2 is the important receptor among VEGFR protiens and its activation and signaling may be positively or negatively regulated by co-expression and activation of various factors and other VEGF receptors like VEGFR-1 (Hicklin and Ellis 2005).The regulatory events of this receptor will be annotated in subsequent modules. |
| (summation) | [Reaction:194310] VEGF-A,C,D bind to VEGFR2 leading to receptor dimerization [Homo sapiens] |
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No pathways have been reviewed or authored by VEGFR-2 binds VEGF-A, -C, -D, and -E homodimers. VEGFR-2 is ... (195572)
