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Details on Person Plasma membrane-associated Neuropilin-1 (NRP1) binds vascula...

Class:IdSummation:195424
_displayNamePlasma membrane-associated Neuropilin-1 (NRP1) binds vascula...
_timestamp2018-05-23 17:03:32
created[InstanceEdit:195420] Gopinathrao, G, 2007-04-06 20:37:55
literatureReference[LiteratureReference:195416] VEGF165 mediates formation of complexes containing VEGFR-2 and neuropilin-1 that enhance VEGF165-receptor binding
modified[InstanceEdit:195561] Gopinathrao, G, 2007-04-09 00:43:51
[InstanceEdit:195566] Gopinathrao, G, 2007-04-09 01:56:10
[InstanceEdit:195642] Gopinathrao, G, 2007-04-11 20:35:02
[InstanceEdit:195643] Gopinathrao, G, 2007-04-11 20:49:16
[InstanceEdit:9609398] D'Eustachio, Peter, 2018-05-23
textPlasma membrane-associated Neuropilin-1 (NRP1) binds vascular endothelial growth factor (VEGF) family members. NRP1 has three distinct extracellular domains, a1a2, b1b2, and c but lacks a distinct intracellular domain. VEGF165 mediates the formation of complexes containing VEGFR-2 and NRP-1, enhancing VEGF165-receptor binding on the endothelial cell membrane (Soker et al. 2002).
(summation)[Reaction:195408] NRP-1 forms a ternary complex with VEGF165 and VEGFR1 [Homo sapiens]
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