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Details on Person Phosphorylation of beta-catenin at Ser45 by CK1 alpha

Class:Id	Reaction:195318
_displayName	Phosphorylation of beta-catenin at Ser45 by CK1 alpha
_doRelease	TRUE
_timestamp	2016-10-31 18:30:34
authored	[InstanceEdit:195289] Kimelman, D, 2007-04-03 12:34:14
catalystActivity	[CatalystActivity:1505509] protein serine/threonine kinase activity of CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol]
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
edited	[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
input	[SimpleEntity:113592] ATP [cytosol] [Complex:3601581] CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:196269] Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway
modified	[InstanceEdit:195321] Matthews, L, 2007-04-03 12:55:17 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:196227] Matthews, L, 2007-04-18 13:51:26 [InstanceEdit:196309] Matthews, L, 2007-04-19 13:47:29 [InstanceEdit:196582] Matthews, L, 2007-04-23 13:54:09 [InstanceEdit:196990] Matthews, L, 2007-04-27 13:06:46 [InstanceEdit:197015] Gopinathrao, G, 2007-04-30 12:28:07 [InstanceEdit:2130744] Rothfels, K, 2012-02-21 [InstanceEdit:4833271] Rothfels, K, 2013-10-29 [InstanceEdit:4837327] Rothfels, K, 2013-10-30 [InstanceEdit:5251608] Rothfels, K, 2014-02-04 [InstanceEdit:5433090] Rothfels, Karen, 2014-05-12 [InstanceEdit:8942378] Rothfels, Karen, 2016-10-13 [InstanceEdit:8943874] Rothfels, Karen, 2016-10-31 [InstanceEdit:8943889] Rothfels, Karen, 2016-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of beta-catenin at Ser45 by CK1 alpha
output	[SimpleEntity:29370] ADP [cytosol] [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Homo sapiens]
precedingEvent	[Reaction:195304] Association of beta-catenin with the destruction complex [Homo sapiens] [Reaction:5229343] AXIN is phosphorylated in the destruction complex [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:196987] Pagano, M, 2007-04-27 13:02:18
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22 [InstanceEdit:5433076] Salahshor, S, 2014-05-12
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361197] R-HSA-195318.3
summation	[Summation:196301] CK1a binds to Axin and phosphorylates beta-catenin at Ser45 ...
(hasEvent)	[Pathway:196299] Beta-catenin phosphorylation cascade [Homo sapiens]
(normalReaction)	[FailedReaction:4827388] CTNNB1 S45 mutants aren't phosphorylated by CK1alpha [Homo sapiens]
(precedingEvent)	[Reaction:195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9782069] Update Tracker - [Reaction:195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - v59:[add_removeInput] [_UpdateTracker:9788781] Update Tracker - [Reaction:195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha - v40:[add_removeCatalystActivity]
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