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Details on Person Beta-catenin associates with the destruction complex through...

Class:IdSummation:195291
_displayNameBeta-catenin associates with the destruction complex through...
_timestamp2007-04-19 13:45:04
created[InstanceEdit:195272] Matthews, L, 2007-04-03 12:38:03
literatureReference[LiteratureReference:196265] Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation
[LiteratureReference:196262] Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
[LiteratureReference:196248] The third 20 amino acid repeat is the tightest binding site of APC for beta-catenin
[LiteratureReference:196293] Molecular mechanisms of beta-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC-beta-catenin complex
modified[InstanceEdit:196287] Matthews, L, 2007-04-19 13:44:57
textBeta-catenin associates with the destruction complex through an interaction with Axin and or APC. This association may also involve interactions with the 15 aa repeats in APC (Spink et al., 2001) or the third APC 20aa repeat and its N-terminal flanking residues (Ha et al., 2004, Xing et al., 2004; Liu et al., 2006).
(summation)[Reaction:195304] Association of beta-catenin with the destruction complex [Homo sapiens]
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