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Details on Person Matthews, L, 2007-04-03 12:38:03
| Class:Id | InstanceEdit:195272 |
| _displayName | Matthews, L, 2007-04-03 12:38:03 |
| _timestamp | 2008-11-19 13:59:57 |
| author | [Person:142011] Matthews, Lisa |
| dateTime | 2007-04-03 16:38:03 |
| (authored) | [BlackBoxEvent:2130282] Degradation of ubiquitinated beta catenin by the proteasome [Homo sapiens] |
| (created) | [Reaction:195275] Phosphorylation of APC component of the destruction complex [Homo sapiens] [Complex:195277] p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Homo sapiens] [Summation:195278] Phospho-(Ser45, Thr41) beta-catenin is phosphorylated by GSK... [Reaction:195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex [Homo sapiens] [Summation:195281] Following CKI-mediated phosphorylation at Ser45, beta-cateni... [Complex:195282] p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] [Homo sapiens] [Reaction:195283] Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 [Homo sapiens] [CandidateSet:195284] CK1alpha (GSK3) [cytosol] [Homo sapiens] [Reaction:195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 [Homo sapiens] [Summation:195288] Beta-catenin is then phosphorylated at Ser33. Phosphorylated... |
| (edited) | [Reaction:195251] Assembly of the destruction complex [Homo sapiens] [Pathway:195253] Degradation of beta-catenin by the destruction complex [Homo sapiens] [Reaction:195275] Phosphorylation of APC component of the destruction complex [Homo sapiens] [Reaction:195280] Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex [Homo sapiens] [Reaction:195283] Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 [Homo sapiens] [Reaction:195287] Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 [Homo sapiens] [Reaction:195300] Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 [Homo sapiens] [Reaction:195304] Association of beta-catenin with the destruction complex [Homo sapiens] [Reaction:195318] Phosphorylation of beta-catenin at Ser45 by CK1 alpha [Homo sapiens] [Pathway:195721] Signaling by WNT [Homo sapiens] |
| (modified) | [Pathway:195253] Degradation of beta-catenin by the destruction complex [Homo sapiens] |
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No pathways have been reviewed or authored by Matthews, L, 2007-04-03 12:38:03 (195272)