Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:Q92974 ARHGEF2

Class:Id	ReferenceGeneProduct:195090
_chainChangeLog	chain:1-986 added on Sat February 7 2015
_displayName	UniProt:Q92974 ARHGEF2
_timestamp	2026-02-20 21:27:30
chain	chain:1-986
checksum	8986AF0A1174EA71
comment	FUNCTION Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity).SUBUNIT Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3. Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser-886. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1. Interacts (via the N-terminal zinc finger) with CAPN6 (via domain II). Interacts with DYNLT1 (By similarity).INTERACTION Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (PubMed:15827085). Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells (PubMed:19043560). Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (PubMed:21887730).ALTERNATIVE PRODUCTS Up-regulated by bacterial peptidoglycans stimulation, such as muramyl dipeptide and in biopsies from inflamed mucosal areas of Crohn's disease patients.DOMAIN The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA. Promotes tyrosine phosphorylation of RIPK2.DOMAIN The PH domain has no affinity for phosphoinositides suggesting that it does not interact directly with membranes.DOMAIN The phorbol-ester/DAG-type zinc-finger and the C-terminal coiled-coil domains (606-986) are both important for association with microtubules.PTM Phosphorylation of Ser-886 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner.DISEASE The disease is caused by variants affecting the gene represented in this entry.SEQUENCE CAUTION Sequence differs at a large extent from the sequence shown in the paper.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION ARHGEF2 entry
created	[InstanceEdit:195085] Gopinathrao, G, 2007-04-02 18:48:36
description	recommendedName: Rho guanine nucleotide exchange factor 2 alternativeName: Guanine nucleotide exchange factor H1 shortName: GEF-H1 alternativeName: Microtubule-regulated Rho-GEF alternativeName: Proliferating cell nucleolar antigen p40
geneName	ARHGEF2 KIAA0651 LFP40
identifier	Q92974
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cell cycle Cell division Cell junction Cell membrane Cell projection Coiled coil Cytoplasm Cytoplasmic vesicle Cytoskeleton Developmental protein Differentiation Golgi apparatus Guanine-nucleotide releasing factor Immunity Innate immunity Intellectual disability Membrane Metal-binding Microtubule Mitosis Neurogenesis Phosphoprotein Proteomics identification Reference proteome Tight junction Zinc Zinc-finger
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
name	ARHGEF2
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8960137] ENSEMBL:ENSG00000116584 ARHGEF2 [Homo sapiens]
secondaryIdentifier	ARHG2_HUMAN D3DVA6 O75142 Q15079 Q5VY92 Q8TDA3 Q8WUG4 Q9H023
sequenceLength	986
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:384454] UniProt:Q92974-2 ARHGEF2 [Homo sapiens] [ReferenceIsoform:384455] UniProt:Q92974-3 ARHGEF2 [Homo sapiens] [ReferenceIsoform:412525] UniProt:Q92974-1 ARHGEF2 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:195101] ARHGEF2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8960357] ARHGEF2 [extracellular region] [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:Q92974 ARHGEF2 (195090)