Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:Q13009 TIAM1
| Class:Id | ReferenceGeneProduct:195051 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-1591 added on Sat February 7 2015;initiator methionine:1 for 195051 removed on Fri Nov 03 2023;initiator methionine: for 195051 added on Fri Nov 03 2023;initiator methionine: for 195051 removed on Fri Aug 15 2025;initiator methionine:1 for 195051 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q13009 TIAM1 |
| _timestamp | 2025-08-15 21:57:39 |
| chain | initiator methionine:1 chain:2-1591 |
| checksum | 0DAFBEE9A84B3452 |
| comment | FUNCTION Guanyl-nucleotide exchange factor that activates RHO-like proteins and connects extracellular signals to cytoskeletal activities. Activates RAC1, CDC42, and to a lesser extent RHOA and their downstream signaling to regulate processes like cell adhesion and cell migration.SUBUNIT Component of the Par polarity complex, composed of at least phosphorylated PRKCZ, PARD3 and TIAM1. Interacts with NTRK2; mediates the activation of RAC1 by BDNF. Interacts with MAPK8IP2 and CD44 (By similarity). Interacts with BAIAP2. Interacts with EPHA8; regulates clathrin-mediated endocytosis of EPHA8. Interacts with PARD3. Interacts (via PDZ domain) with CNTNAP4, SDC1 and SDC3 (via C-terminus).INTERACTION Detected at the boundary between cells with actin-rich protrusions (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.ALTERNATIVE PRODUCTS Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.DOMAIN The first PH domain mediates interaction with membranes enriched in phosphoinositides.PTM Ubiquitinated. Undergoes 'Lys-48' ubiquitination at Lys-1404 and Lys-1420 by a CUL3(KBTBD6/7) E3 ubiquitin ligase complex composed of CUL3, RBX1, KBTBD6 and KBTBD7. 'Lys-48' ubiquitination at Lys-1404 and Lys-1420 triggers proteasomal degradation (PubMed:25684205). Ubiquitination at Lys-1404 and Lys-1420 by CUL3(KBTBD6/7) also requires the membrane-associated protein GABARAP and may therefore be spatially restricted within the cell (PubMed:25684205).DISEASE The disease may be caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TIAM family. |
| created | [InstanceEdit:195029] Gopinathrao, G, 2007-04-02 17:19:01 |
| description | recommendedName: fullName evidence="25"Rho guanine nucleotide exchange factor TIAM1 alternativeName: fullName evidence="2"T-lymphoma invasion and metastasis-inducing protein 1 shortName evidence="2"TIAM-1 |
| geneName | TIAM1 |
| identifier | Q13009 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell junction Cell membrane Epilepsy Guanine-nucleotide releasing factor Intellectual disability Isopeptide bond Lipid-binding Lipoprotein Membrane Myristate Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | TIAM1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994557] ENSEMBL:ENSG00000156299 TIAM1 [Homo sapiens] |
| secondaryIdentifier | TIAM1_HUMAN B7ZLR6 F5GZ53 Q17RT7 |
| sequenceLength | 1591 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970783] UniProt:Q13009-1 TIAM1 [Homo sapiens] [ReferenceIsoform:8970784] UniProt:Q13009-2 TIAM1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:195013] TIAM1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:3928461] p-Y829-TIAM1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9970162] p-Y-TIAM1 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:3928455] O4'-phospho-L-tyrosine at 829 [ModifiedResidue:9970160] O4'-phospho-L-tyrosine at unknown position |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q13009 TIAM1 (195051)
