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Details on Person UniProt:O60229-1 KALRN
| Class:Id | ReferenceIsoform:195045 |
|---|---|
| _chainChangeLog | chain:1-2985 added on Fri February 6 2015;chain:1-2985 for 195045 removed on Fri August 9 2019;chain:1-2986 for 195045 added on Fri August 9 2019 |
| _displayName | UniProt:O60229-1 KALRN |
| _timestamp | 2025-02-21 19:08:02 |
| chain | chain:1-2986 |
| checksum | EA7B559A9E4AFFA0 |
| comment | FUNCTION Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.INTERACTION Associated with the cytoskeleton.ALTERNATIVE PRODUCTS Isoform 2 is brain specific. Highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.DOMAIN The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity).PTM Autophosphorylated.MISCELLANEOUS Called DUO because the encoded protein is closely related to but shorter than TRIO.SIMILARITY Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Probable cloning artifact. |
| created | [InstanceEdit:195029] Gopinathrao, G, 2007-04-02 17:19:01 |
| description | recommendedName: fullName evidence="3"Kalirin ecNumber: 2.7.11.1 alternativeName: Huntingtin-associated protein-interacting protein alternativeName: Protein Duo alternativeName: Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain |
| geneName | KALRN DUET DUO HAPIP TRAD |
| identifier | O60229 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing ATP-binding Cytoplasm Cytoskeleton Disulfide bond Guanine-nucleotide releasing factor Immunoglobulin domain Kinase Magnesium Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Repeat Serine/threonine-protein kinase SH3 domain Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | KALRN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990197] ENSEMBL:ENSG00000160145 KALRN [Homo sapiens] |
| secondaryIdentifier | KALRN_HUMAN A0A804HLI0 A8MSI4 C9JQ37 J3QSW6 Q6ZN45 Q8TBQ5 Q9NSZ4 Q9Y2A5 |
| sequenceLength | 2986 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | O60229-1 |
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No pathways have been reviewed or authored by UniProt:O60229-1 KALRN (195045)
