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Details on Person UniProt:O15068 MCF2L

Class:Id	ReferenceGeneProduct:195027
_chainChangeLog	chain:1-1137 added on Fri February 6 2015
_displayName	UniProt:O15068 MCF2L
_timestamp	2024-11-03 19:46:56
chain	chain:1-1137
checksum	B2830890A69C8377
comment	FUNCTION Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669).FUNCTION Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669).SUBUNIT Interacts with GTP-bound RAC1 (By similarity). Interacts with CDC42 (PubMed:15157669). Interacts with RHOA. Interacts with CCPG1, which results in specific inhibition of its exchange activity toward RHOA, but does not affect its activity on CDC42 (By similarity).INTERACTION Interaction with membranes enriched in phosphoinositides is mediated by the CRAL-TRIO domain.SUBCELLULAR LOCATION A number of isoforms are produced. According to EST sequences. Experimental confirmation may be lacking for some isoforms.DOMAIN The CRAL-TRIO domain mediates interaction with various inositol phospholipids, such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P).DOMAIN The DH domain is involved in interaction with CCPG1.SIMILARITY Belongs to the MCF2 family.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:195029] Gopinathrao, G, 2007-04-02 17:19:01
description	recommendedName: Guanine nucleotide exchange factor DBS alternativeName: DBL's big sister alternativeName: MCF2-transforming sequence-like protein
geneName	MCF2L KIAA0362 OST
identifier	O15068
isSequenceChanged	FALSE
keyword	Alternative splicing Cell membrane Coiled coil Cytoplasm Guanine-nucleotide releasing factor Lipid-binding Membrane Phosphoprotein Proteomics identification Proto-oncogene Reference proteome SH3 domain
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	MCF2L
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8991968] ENSEMBL:ENSG00000126217 MCF2L [Homo sapiens]
secondaryIdentifier	MCF2L_HUMAN A2A2X1 A2A2X2 A2A3G6 A2A3G8 B4DHD6 B4DIL6 E9PDN8 Q5JU56 Q5VXT1 Q6ZWD4 Q765G8 Q765G9 Q8N679
sequenceLength	1137
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:236846] UniProt:O15068-2 MCF2L [Homo sapiens] [ReferenceIsoform:236847] UniProt:O15068-3 MCF2L [Homo sapiens] [ReferenceIsoform:236848] UniProt:O15068-4 MCF2L [Homo sapiens] [ReferenceIsoform:236849] UniProt:O15068-5 MCF2L [Homo sapiens] [ReferenceIsoform:236850] UniProt:O15068-6 MCF2L [Homo sapiens] [ReferenceIsoform:236852] UniProt:O15068-8 MCF2L [Homo sapiens] [ReferenceIsoform:401297] UniProt:O15068-1 MCF2L [Homo sapiens] [ReferenceIsoform:8969747] UniProt:O15068-10 MCF2L [Homo sapiens] [ReferenceIsoform:8969748] UniProt:O15068-9 MCF2L [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:195070] MCF2L [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:O15068 MCF2L (195027)