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Details on Person UniProt:O14827 RASGRF2
| Class:Id | ReferenceGeneProduct:194943 |
|---|---|
| _chainChangeLog | chain:1-1237 added on Fri February 6 2015 |
| _displayName | UniProt:O14827 RASGRF2 |
| _timestamp | 2024-11-03 19:53:37 |
| chain | chain:1-1237 |
| checksum | A136CF4FA111FDD9 |
| comment | FUNCTION Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.SUBUNIT Homooligomer and heterooligomer with RASGRF1. Interacts with Ras and RAC1. Interacts in a calcium-dependent manner with calmodulin (By similarity). Interacts with CDK5R1 and EPB49. Interacts with the AMPA receptor through GRIA1 (By similarity). Interacts with microtubules (By similarity).SUBCELLULAR LOCATION Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity).TISSUE SPECIFICITY Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).DOMAIN The Ras-GEF domain and the N-terminal Ras-GEF domain form a Ras-binding site and mediate Ras activation.DOMAIN The IQ domain mediates the calcium-dependent interaction with calmodulin but is dispensable for the Ras-GEF activity.DOMAIN The DH (DBL-homology) domain mediates interaction with RASGRF1 and EPB49 and is required for RAC1 activation.PTM Phosphorylated by CDK5; down-regulates RASGRF2-mediated RAC1 activation.PTM Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome (By similarity). |
| created | [InstanceEdit:194938] Gopinathrao, G, 2007-03-31 01:47:51 |
| description | recommendedName: Ras-specific guanine nucleotide-releasing factor 2 shortName: Ras-GRF2 alternativeName: Ras guanine nucleotide exchange factor 2 |
| geneName | RASGRF2 GRF2 |
| identifier | O14827 |
| isSequenceChanged | FALSE |
| keyword | Calcium Calmodulin-binding Cell membrane Coiled coil Cytoplasm Endoplasmic reticulum Guanine-nucleotide releasing factor Membrane Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | RASGRF2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996216] ENSEMBL:ENSG00000113319 RASGRF2 [Homo sapiens] |
| secondaryIdentifier | RGRF2_HUMAN B9EG89 Q9UK56 |
| sequenceLength | 1237 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:194944] RASGRF2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:442744] RASGRF2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O14827 RASGRF2 (194943)
