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Details on Person UniProt:Q8IXI2-4 RHOT1
| Class:Id | ReferenceIsoform:194895 |
|---|---|
| _chainChangeLog | chain:1-618 added on Fri February 6 2015 |
| _displayName | UniProt:Q8IXI2-4 RHOT1 |
| _timestamp | 2025-08-15 22:01:54 |
| chain | chain:1-618 |
| checksum | FE47AC3A4AF6F6C2 |
| comment | FUNCTION Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). Promotes mitochondrial fission during high calcium conditions (PubMed:27716788). Can hydrolyze GTP, ATP and UTP (PubMed:30513825).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)CATALYTIC ACTIVITY ATP + H2O = ADP + phosphate + H(+)CATALYTIC ACTIVITY UTP + H2O = UDP + phosphate + H(+)SUBUNIT Homodimer (PubMed:27605430, PubMed:33132189). Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (PubMed:16630562). Interacts with RAP1GDS1 (PubMed:27716788). Interacts with ARMCX1 (By similarity). Found in a complex with KIF5B, OGT, RHOT2 and TRAK1 (PubMed:24995978).INTERACTION Colocalizes with MGARP and RHOT2 at the mitochondria.ALTERNATIVE PRODUCTS Ubiquitously expressed. Expressed at high level in heart and skeletal muscle.DOMAIN The Miro 2 domain is necessary for efficient ubiquitination by PRKN.PTM Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy (PubMed:22396657, PubMed:24896179, PubMed:27605430). Deubiquitinated by USP30 (PubMed:24896179).PTM Acetylation on Lys-92 decreases sensitivity of mitochondrial transport to elevated Ca(2+) levels, increases mitochondrial transport and promotes axon growth. Deacetylated by HDAC6 which blocks mitochondrial transport and mediates axon growth inhibition.SIMILARITY Belongs to the mitochondrial Rho GTPase family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:194867] Gopinathrao, G, 2007-03-30 18:18:39 |
| description | recommendedName: Mitochondrial Rho GTPase 1 shortName: MIRO-1 shortName: hMiro-1 ecNumber evidence="15"3.6.5.- alternativeName: Rac-GTP-binding protein-like protein alternativeName: Ras homolog gene family member T1 |
| geneName | RHOT1 ARHT1 |
| identifier | Q8IXI2 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Calcium GTP-binding Hydrolase Isopeptide bond Membrane Metal-binding Mitochondrion Mitochondrion outer membrane Nucleotide-binding Proteomics identification Reference proteome Repeat Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | RHOT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996107] ENSEMBL:ENSG00000126858 RHOT1 [Homo sapiens] |
| secondaryIdentifier | MIRO1_HUMAN A4FVB6 A6NFV0 B4DG48 J9JIH9 Q6NUR3 Q6P9F8 Q6PJG1 Q6YMW8 Q86UB0 Q8IW28 Q8IXJ7 Q9H067 Q9H9N8 Q9NUZ2 |
| sequenceLength | 618 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q8IXI2-4 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8IXI2-4 RHOT1 (194895)
