Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person botB LC cleaves target cell VAMP2

Class:Id	Reaction:194796
_displayName	botB LC cleaves target cell VAMP2
_doRelease	TRUE
_timestamp	2020-10-08 22:00:33
authored	[InstanceEdit:194836] Krupa, S, Gopinathrao, G, 2006-06-15 10:36:11
catalystActivity	[CatalystActivity:181676] metalloendopeptidase activity of botB LC:Zn2+ [cytosol]
catalystActivityReference	[CatalystActivityReference:9643194] metalloendopeptidase activity of BoNT/B LC:Zn2+ [cytosol] Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
compartment	[Compartment:70101] cytosol [Compartment:201753] synaptic vesicle membrane
created	[InstanceEdit:194803] Gopinathrao, G, 2007-03-27 17:24:22
disease	[Disease:3632909] botulism
edited	[InstanceEdit:181692] Gopinathrao, G, 2006-06-15 22:12:29
input	[EntityWithAccessionedSequence:181517] VAMP2 [synaptic vesicle membrane] [Homo sapiens]
literatureReference	[LiteratureReference:181771] Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments [LiteratureReference:5228352] Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin [LiteratureReference:5263580] Membrane fusion machinery: insights from synaptic proteins [LiteratureReference:379281] The synaptic vesicle cycle
modified	[InstanceEdit:194837] Gopinathrao, G, 2007-03-29 10:41:15 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197013] Gopinathrao, G, 2007-04-30 09:21:41 [InstanceEdit:200989] Gopinathrao, G, 2007-07-27 15:43:30 [InstanceEdit:201181] Gopinathrao, G, 2007-08-01 20:04:38 [InstanceEdit:201316] Gopinathrao, G, 2007-08-03 18:19:30 [InstanceEdit:201332] Gopinathrao, G, 2007-08-06 14:46:29 [InstanceEdit:2648976] D'Eustachio, P, 2012-11-21 [InstanceEdit:2660809] D'Eustachio, P, 2012-11-23 [InstanceEdit:3632911] Gillespie, ME, 2013-05-28 [InstanceEdit:5228354] D'Eustachio, Peter, 2014-01-10 [InstanceEdit:5246515] D'Eustachio, Peter, 2014-01-21 [InstanceEdit:5263577] D'Eustachio, Peter, 2014-02-11 [InstanceEdit:5365822] D'Eustachio, Peter, 2014-04-23 [InstanceEdit:5606956] Gillespie, Marc E, 2014-07-07 [InstanceEdit:5617438] Gillespie, Marc E, 2014-08-08 [InstanceEdit:5643760] D'Eustachio, Peter, 2014-11-17 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9704403] D'Eustachio, Peter, 2020-10-08 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	botB LC cleaves target cell VAMP2
output	[EntityWithAccessionedSequence:194802] VAMP2(2-76) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5228355] VAMP2(77-116) [synaptic vesicle membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:5244404] botB HC transports botB LC from target cell synaptic vesicle membrane into cytosol [Homo sapiens] [BlackBoxEvent:5244402] botB:SYT:GT1b internalized from target cell plasma membrane to synaptic vesicle membrane [Homo sapiens]
relatedSpecies	[Species:168825] Clostridium botulinum
releaseDate	2007-08-21
reviewed	[InstanceEdit:201311] Ichtchenko, K, 2007-08-03 18:17:25 [InstanceEdit:5643756] Thirunavukkarasu, Nagarajan, Sharma, Shashi, 2014-11-17
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5263589] D'Eustachio, Peter, 2014-02-10
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359766] R-HSA-194796.4
summation	[Summation:201309] Botulinum toxin type B light chain (botB LC), in the cytosol...
(hasEvent)	[Pathway:5250958] Toxicity of botulinum toxin type B (botB) [Homo sapiens]
(replacementInstances)	[_Deleted:5250998] Deletion of instance: 168769
(updatedInstance)	[_UpdateTracker:9776484] Update Tracker - [Reaction:194796] botB LC cleaves target cell VAMP2 - v75:[modifyText] [_UpdateTracker:9785957] Update Tracker - [Reaction:194796] botB LC cleaves target cell VAMP2 - v50:[modifyText] [_UpdateTracker:9786792] Update Tracker - [Reaction:194796] botB LC cleaves target cell VAMP2 - v48:[addOutput, add_removeLiteratureReference, modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by botB LC cleaves target cell VAMP2 (194796)