Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person 4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)

Class:Id	Reaction:194718
_displayName	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)
_doRelease	TRUE
_timestamp	2025-04-11 19:40:10
authored	[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
catalystActivity	[CatalystActivity:194724] 3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity of NSDHL [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:194683] D'Eustachio, P, 2007-03-22 16:07:19
crossReference	[DatabaseIdentifier:9945219] RHEA:33455
edited	[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
input	[SimpleEntity:194657] 4CZYMOL [endoplasmic reticulum membrane] [SimpleEntity:29360] NAD+ [cytosol]
literatureReference	[LiteratureReference:194694] NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets
modified	[InstanceEdit:195713] D'Eustachio, P, 2007-04-13 17:54:25 [InstanceEdit:196422] D'Eustachio, P, 2007-04-21 18:35:08 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9945226] D'Eustachio, Peter, 2025-04-11
name	4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) 4α-carboxyzymosterol + NADP+ = zymosterone + CO2 + NADPH
output	[SimpleEntity:194661] ZYMONE [endoplasmic reticulum membrane] [SimpleEntity:113528] CO2 [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:73473] NADH [cytosol]
precedingEvent	[Reaction:194669] 4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol [Homo sapiens] [Reaction:194689] 4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol [Homo sapiens]
releaseDate	2007-02-20
reviewed	[InstanceEdit:196409] Jassal, B, 2007-04-21 18:33:24
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361582] R-HSA-194718.3
summation	[Summation:194673] 4-carboxycholesta-8(9),24-dien-3beta-ol and NAD+ react to fo...
(hasEvent)	[Pathway:6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) [Homo sapiens]
(precedingEvent)	[Reaction:194632] Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol) [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by 4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone) (194718)