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Details on Person CYP51A1 demethylates LAN

Class:IdReaction:194678
_displayNameCYP51A1 demethylates LAN
_doReleaseTRUE
_timestamp2025-10-22 21:36:30
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:194693] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen of CYP51A1 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:194683] D'Eustachio, P, 2007-03-22 16:07:19
crossReference[DatabaseIdentifier:9907888] RHEA:25287
edited[InstanceEdit:196418] D'Eustachio, P, 2007-04-21 18:31:40
input[SimpleEntity:194634] LAN [endoplasmic reticulum membrane]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:29368] O2 [cytosol]
literatureReference[LiteratureReference:194658] The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols
[LiteratureReference:5602275] Structural basis of human CYP51 inhibition by antifungal azoles
modified[InstanceEdit:195713] D'Eustachio, P, 2007-04-13 17:54:25
[InstanceEdit:196422] D'Eustachio, P, 2007-04-21 18:35:08
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351778] Jassal, Bijay, 2008-05-28
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907889] D'Eustachio, Peter, 2024-04-17
[InstanceEdit:9945226] D'Eustachio, Peter, 2025-04-11
[InstanceEdit:9969571] D'Eustachio, Peter, 2025-10-22
nameCYP51A1 demethylates LAN
lanosterol + 3 O2 + 3 reduced (NADPH--hemoprotein reductase) => 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + 4 H(+) + 4 H2O + 3 oxidized (NADPH--hemoprotein reductase)
lanosterol + 3 NADPH + 3 H+ + 3 O2 => 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol + 3 NADP+ + 4 H2O + formate
output[SimpleEntity:194644] 4,4DMCHtOL [endoplasmic reticulum membrane]
[SimpleEntity:29460] HCOOH [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
precedingEvent
releaseDate2007-02-20
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360595] R-HSA-194678.5
summation[Summation:194660] Lanosterol 14-alpha demethylase (CYP51A1) catalyses oxidativ...
(hasEvent)[Pathway:211976] Endogenous sterols [Homo sapiens]
[Pathway:6807047] Cholesterol biosynthesis via desmosterol (Bloch pathway) [Homo sapiens]
(precedingEvent)[Reaction:194641] 4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol [Homo sapiens]
[Reaction:194674] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [LBR] [Homo sapiens]
[Reaction:194698] 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol is reduced to 4,4-dimethylcholesta-8(9),24-dien-3beta-ol [TM7SF2] [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786284] Update Tracker - [Reaction:194678] CYP51A1 demethylates LNSOL - v50:[addLiteratureReference, modifyText]
[_UpdateTracker:9971812] Update Tracker - [Reaction:194678] CYP51A1 demethylates LAN - v95:[modifyText]
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