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Details on Person Lanosterol 14-alpha demethylase (CYP51A1) catalyses oxidativ...

Class:IdSummation:194660
_displayNameLanosterol 14-alpha demethylase (CYP51A1) catalyses oxidativ...
_timestamp2025-10-22 21:36:31
created[InstanceEdit:194683] D'Eustachio, P, 2007-03-22 16:07:19
literatureReference[LiteratureReference:194651] Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate.
[LiteratureReference:194654] Microsomal enzymes of cholesterol biosynthesis. Purification of lanosterol 14 alpha-methyl demethylase cytochrome P-450 from hepatic microsomes.
[LiteratureReference:194670] Membrane-bound enzymes of cholesterol synthesis from lanosterol
modified[InstanceEdit:196558] Jassal, B, 2007-04-23 12:58:47
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9969571] D'Eustachio, Peter, 2025-10-22
textLanosterol 14-alpha demethylase (CYP51A1) catalyses oxidative C14-demethylation of lanosterol (LAN) to 4,4-dimethylcholesta-8(9),14,24-trien-3beta-ol (4,4DMCHOLtrienol). Although the reaction is annotated here as a single concerted event, studies with purified rat enzyme indicate that the methyl group is converted successively to an alcohol and an aldehyde before being released as formate (Stromstedt et al. 1996, Strushkevich et al. 2010).
(summation)[Reaction:194678] CYP51A1 demethylates LAN [Homo sapiens]
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