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Details on Person VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization

Class:IdReaction:194311
_displayNameVEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization
_doReleaseTRUE
_timestamp2017-10-23 12:25:01
authored[InstanceEdit:4420157] Garapati, P V, 2013-08-30
compartment[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created[InstanceEdit:194309] Gopinathrao, G, 2007-03-12 19:24:15
edited[InstanceEdit:4420157] Garapati, P V, 2013-08-30
figure[Figure:195519] /figures/vegfr1.jpg
input[DefinedSet:195389] VEGFA,VEGFB,PGF dimers [extracellular region] [Homo sapiens]
[EntityWithAccessionedSequence:3004464] VEGFR1 [plasma membrane] [Homo sapiens]
[EntityWithAccessionedSequence:3004464] VEGFR1 [plasma membrane] [Homo sapiens]
literatureReference[LiteratureReference:195484] A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells
[LiteratureReference:195498] Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules
[LiteratureReference:195485] Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site
[LiteratureReference:195521] Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders
[LiteratureReference:195503] Vascular endothelial growth factor is a secreted angiogenic mitogen
[LiteratureReference:195458] Vascular endothelial growth factor B, a novel growth factor for endothelial cells
modified[InstanceEdit:195388] Gopinathrao, G, 2007-04-06 13:52:39
[InstanceEdit:195445] Gopinathrao, G, 2007-04-08 22:12:41
[InstanceEdit:195494] Gopinathrao, G, 2007-04-08 23:52:30
[InstanceEdit:195566] Gopinathrao, G, 2007-04-09 01:56:10
[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197012] Gopinathrao, G, 2007-04-30 09:18:35
[InstanceEdit:212467] Gopinathrao, G, 2008-02-11 22:09:46
[InstanceEdit:213342] Gopinathrao, G, 2008-02-25 19:55:12
[InstanceEdit:215138] Gopinathrao, G, 2008-02-27 18:32:21
[InstanceEdit:215190] Gopinathrao, G, 2008-02-27 20:26:33
[InstanceEdit:215258] Gopinathrao, G, 2008-02-28 00:16:26
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:3004463] Jupe, S, 2013-01-29
[InstanceEdit:5432677] Garapati, P V, 2014-05-12
[InstanceEdit:5490368] Garapati, P V, 2014-05-19
[InstanceEdit:5545454] Garapati, P V, 2014-05-21
[InstanceEdit:9026719] Rothfels, Karen, 2017-10-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameVEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization
output[Complex:195396] VEGFR1 dimer:VEGFA, VEGFB, PGF dimers [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2008-03-12
reviewed[InstanceEdit:215257] Claesson-Welsh, L, 2008-02-28 00:15:17
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:362020] R-HSA-194311.3
summation[Summation:195576] VEGFR-1 binds VEGF-A, VEGF-B, and PLGF homodimers. This inte...
(hasEvent)[Pathway:195399] VEGF binds to VEGFR leading to receptor dimerization [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786417] Update Tracker - [Reaction:194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - v49:[removeLiteratureReference]
[_UpdateTracker:9787950] Update Tracker - [Reaction:194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - v44:[add_removeInput]
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