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Details on Person VEGF-C,D bind to VEGFR3 leading to receptor dimerization

Class:Id	Reaction:194308
_displayName	VEGF-C,D bind to VEGFR3 leading to receptor dimerization
_doRelease	TRUE
_timestamp	2017-10-23 12:24:55
authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:194309] Gopinathrao, G, 2007-03-12 19:24:15
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
figure	[Figure:195461] /figures/vegfr3.jpg
input	[DefinedSet:195391] VEGFC,VEGFD dimers [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:195359] FLT4 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:195359] FLT4 [plasma membrane] [Homo sapiens]
literatureReference	[LiteratureReference:195459] Ligand-induced vascular endothelial growth factor receptor-3 (VEGFR-3) heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites [LiteratureReference:195510] A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases [LiteratureReference:195496] Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4) [LiteratureReference:195452] Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4 [LiteratureReference:195528] Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3
modified	[InstanceEdit:195388] Gopinathrao, G, 2007-04-06 13:52:39 [InstanceEdit:195445] Gopinathrao, G, 2007-04-08 22:12:41 [InstanceEdit:195494] Gopinathrao, G, 2007-04-08 23:52:30 [InstanceEdit:195537] Gopinathrao, G, 2007-04-09 00:21:49 [InstanceEdit:195566] Gopinathrao, G, 2007-04-09 01:56:10 [InstanceEdit:195650] D'Eustachio, P, 2007-04-12 14:09:14 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:196904] Gopinathrao, G, 2007-04-25 14:49:05 [InstanceEdit:197012] Gopinathrao, G, 2007-04-30 09:18:35 [InstanceEdit:212467] Gopinathrao, G, 2008-02-11 22:09:46 [InstanceEdit:213342] Gopinathrao, G, 2008-02-25 19:55:12 [InstanceEdit:215138] Gopinathrao, G, 2008-02-27 18:32:21 [InstanceEdit:215190] Gopinathrao, G, 2008-02-27 20:26:33 [InstanceEdit:215258] Gopinathrao, G, 2008-02-28 00:16:26 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:5490368] Garapati, P V, 2014-05-19 [InstanceEdit:9026718] Rothfels, Karen, 2017-10-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VEGF-C,D bind to VEGFR3 leading to receptor dimerization
output	[Complex:215140] VEGFR3 dimer:VEGFC, VEGFD dimers [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:195378] Homodimerization of VEGF proteins [Homo sapiens]
releaseDate	2008-03-12
reviewed	[InstanceEdit:215257] Claesson-Welsh, L, 2008-02-28 00:15:17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361486] R-HSA-194308.3
summation	[Summation:195563] VEGFR-3 preferentially binds VEGF-C and -D. Mutations of the...
(hasEvent)	[Pathway:195399] VEGF binds to VEGFR leading to receptor dimerization [Homo sapiens]
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