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Details on Person A molecule of extracellular glycocholate or taurocholate is ...
| Class:Id | Summation:194106 |
|---|---|
| _displayName | A molecule of extracellular glycocholate or taurocholate is ... |
| _timestamp | 2007-03-08 15:03:09 |
| created | [InstanceEdit:194078] D'Eustachio, P, 2007-03-08 15:03:08 |
| literatureReference | [LiteratureReference:193474] Enterohepatic bile salt transporters in normal physiology and liver disease [LiteratureReference:194094] Bile salt transporters: molecular characterization, function, and regulation |
| text | A molecule of extracellular glycocholate or taurocholate is transported into the cytosol, mediated by OATP-8 (SLCO1B3) in the plasma membrane. Glycocholate and taurocholate exist in the blood as complexes with serum albumin, and their uptake by OATP-8 must involve disruption of these complexes, but the molecular mechanism coupling disruption and uptake is unknown. In the body, OATP-8 is expressed on the basolateral surfaces of hepatocytes and may play a role in the uptake of glycocholate and taurocholate by the liver under physiological conditions (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). |
| (summation) | [Reaction:194079] SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol [Homo sapiens] |
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No pathways have been reviewed or authored by A molecule of extracellular glycocholate or taurocholate is ... (194106)
