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Details on Person A molecule of extracellular bile salt (glyco- or taurocholat...
| Class:Id | Summation:194087 |
|---|---|
| _displayName | A molecule of extracellular bile salt (glyco- or taurocholat... |
| _timestamp | 2007-03-08 15:03:09 |
| created | [InstanceEdit:194078] D'Eustachio, P, 2007-03-08 15:03:08 |
| literatureReference | [LiteratureReference:193474] Enterohepatic bile salt transporters in normal physiology and liver disease [LiteratureReference:194094] Bile salt transporters: molecular characterization, function, and regulation |
| text | A molecule of extracellular bile salt (glyco- or taurocholate or taurochenodeoxycholate) or bile acid (cholate or chenodeoxycholate) is transported into the cytosol, mediated by OATP-A (SLCO1A2) in the plasma membrane. Bile salts and acids exist in the blood as complexes with serum albumin, and their uptake by OATP-A must involve disruption of this complex, but the molecular mechanism coupling release of a bile salt or acid from albumin to its uptake by OATP-A is unknown. In the body, OATP-A is expressed only at low levels on the basolateral surfaces of hepatocytes and may play only a minor role in the uptake of bile salts and acids by the liver (Kullak-Ublick et al. 2004; Trauner and Boyer 2002). |
| (summation) | [Reaction:194130] Transport (influx) of bile salts and acids by OATP-A [Homo sapiens] |
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