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Details on Person NFKB1(1-433):RELA [nucleoplasm]

Class:IdComplex:194047
_displayNameNFKB1(1-433):RELA [nucleoplasm]
_timestamp2017-07-13 16:42:30
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:194046] Jassal, B, 2007-03-07 10:15:04
goCellularComponent[GO_CellularComponent:7658] transcription regulator complex
hasComponent
modified[InstanceEdit:194346] Jassal, B, 2007-03-13 16:41:41
[InstanceEdit:1606715] D'Eustachio, P, 2011-09-24
[InstanceEdit:9012434] Duenas, Corina, 2017-07-13
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9658105] Weiser, JD, 2019-08-09
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9666277] Weiser, JD, 2019-11-04
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9676538] Cook, Justin, 2020-02-17
[InstanceEdit:9689079] Cook, Justin, 2020-05-15
[InstanceEdit:9689079] Cook, Justin, 2020-05-15
[InstanceEdit:9715688] Shorser, Solomon, 2021-02-17
[InstanceEdit:9729976] Shorser, Solomon, 2021-05-05
[InstanceEdit:9750461] Weiser, JD, 2021-08-11
[InstanceEdit:9757984] Weiser, JD, 2021-11-08
[InstanceEdit:9767390] Wright, Adam, 2022-02-25
[InstanceEdit:9773515] Weiser, Joel, 2022-05-04
[InstanceEdit:9909910] Weiser, Joel, 2024-05-14
[InstanceEdit:9917728] Weiser, Joel, 2024-08-09
[InstanceEdit:9926726] Weiser, Joel, 2024-11-03
[InstanceEdit:9939161] Weiser, Joel, 2025-02-21
[InstanceEdit:9948552] Weiser, Joel, 2025-05-21
[InstanceEdit:9963749] Weiser, Joel, 2025-08-15
[InstanceEdit:9970792] Weiser, Joel, 2025-10-31
[InstanceEdit:9983308] Weiser, Joel, 2026-02-22
[InstanceEdit:9989150] Weiser, Joel, 2026-05-15
nameNFKB1(1-433):RELA
NF-kB complex
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:364429] R-HSA-194047.20
(activeUnit)[PositiveRegulation:3857306] Positive regulation by 'p-T235,S321-CEBPB:NF-kB:IL8 Gene [nucleoplasm]'
[PositiveRegulation:3857316] Positive regulation by 'p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9946733] Positive gene expression regulation by 'BATF:CEBPA:HOXC4:RELA:NFKB2:TCF3:E2F2:PAX5:IRF8:STAT6:MYB:E2F5,7,8:AICDA gene [nucleoplasm]'
[PositiveGeneExpressionRegulation:9959031] Positive gene expression regulation by 'NFKB(1-433):RELA:IL6 gene [nucleoplasm]'
(hasCandidate)[CandidateSet:9909619] NFKB_Complex [nucleoplasm] [Homo sapiens]
(hasComponent)[Complex:3857319] p-T235,S321-CEBPB:NF-kB:IL8 Gene [nucleoplasm] [Homo sapiens]
[Complex:3857324] p-T235,S321-CEBPB:NF-kB:IL6 gene [nucleoplasm] [Homo sapiens]
[Complex:9015003] NFKB1(1-433):RELA:miR-23b gene [nucleoplasm] [Homo sapiens]
[Complex:9016603] IL33:NFKB1(1-433):RELA [nucleoplasm] [Homo sapiens]
[Complex:9795931] NFE2L2 gene:NFkB complex [nucleoplasm] [Homo sapiens]
[Complex:9938037] BATF:CEBPA:HOXC4:RELA:NFKB2:TCF3:E2F2:PAX5:IRF8:STAT6:MYB:E2F5,7,8:AICDA gene [nucleoplasm] [Homo sapiens]
[Complex:9959033] NFKB(1-433):RELA:IL6 gene [nucleoplasm] [Homo sapiens]
(hasMember)[DefinedSet:1168608] NF-kappaB p50,p65,c-Rel dimer [nucleoplasm] [Homo sapiens]
(input)[Reaction:3857305] Activated CEBPB and NFKB complex bind IL6 promoter [Homo sapiens]
[Reaction:3857308] Activated CEBPB and NFKB complex bind IL8 promoter [Homo sapiens]
[Reaction:5624473] Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit [Homo sapiens]
[BlackBoxEvent:8980347] miRNA-23b upregulated after NFKB activation by IL17-IL17R interaction [Homo sapiens]
[BlackBoxEvent:9015004] NFKB1(1-433):RELA binds to miR23a gene [Homo sapiens]
[BlackBoxEvent:9016605] Unconfirmed - IL33 binds NFKB1(1-433):RELA [Homo sapiens]
[Reaction:9796056] NFkB binds the NFE2L2 gene [Homo sapiens]
[Reaction:9938034] BATF, CEBPA, HOXC4, RELA:NFKB1, NFKB2:RELB, TCF3:E2F2, PAX5, IRF8, STAT6, MYB, and E2F5,7,8 bind the AICDA gene [Homo sapiens]
[Reaction:9958869] Activated NFκB complex binds IL6 gene promoter [Homo sapiens]
(output)[Reaction:193691] NF-kB migrates to the nucleus and turns on transcription [Homo sapiens]
[BlackBoxEvent:2730894] NFKB1:RELA translocates from the cytosol to the nucleus [Homo sapiens]
[BlackBoxEvent:9958872] RAC1, CDC42 activate NFκB [Homo sapiens]
(regulator)[NegativeGeneExpressionRegulation:976211] Negative gene expression regulation by 'NFKB1(1-433):RELA [nucleoplasm]'
[PositiveGeneExpressionRegulation:5660621] Positive gene expression regulation by 'NFKB1(1-433):RELA [nucleoplasm]'
(updatedInstance)[_UpdateTracker:9897514] Update Tracker - [Complex:194047] NFKB1(1-433):RELA [nucleoplasm] - v62:[addName]
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No pathways have been reviewed or authored by NFKB1(1-433):RELA [nucleoplasm] (194047)
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