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Details on Person HSD11B2,HSD11B1 dimer oxidise CORT to COR

Class:Id	Reaction:194023
_displayName	HSD11B2,HSD11B1 dimer oxidise CORT to COR
_doRelease	TRUE
_timestamp	2025-09-23 18:22:21
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193976] 11-beta-hydroxysteroid dehydrogenase (NAD+) activity of HSD11B2, HSD11B1 dimer [endoplasmic reticulum membrane]
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:194008] Jassal, B, 2007-03-06 13:54:16
crossReference	[DatabaseIdentifier:9913421] RHEA:68618
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input	[SimpleEntity:193977] CORT [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
literatureReference	[LiteratureReference:193983] The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization. [LiteratureReference:5693387] Mineralocorticoid activity of liquorice: 11-beta-hydroxysteroid dehydrogenase deficiency comes of age
modified	[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:5693377] Jassal, Bijay, 2015-05-15 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9913422] D'Eustachio, Peter, 2024-06-13 [InstanceEdit:9966633] D'Eustachio, Peter, 2025-09-23
name	HSD11B2,HSD11B1 dimer oxidise CORT to COR cortisol + NADP(+) => cortisone + H(+) + NADPH
output	[SimpleEntity:194035] COR [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol]
precedingEvent	[BlackBoxEvent:194036] Cortisol translocates from the mitochondrial matrix to the cytosol [Homo sapiens] [Reaction:193997] CYP11B1 oxidises 11DCORT [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5693397] Jassal, Bijay, 2015-05-15
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359222] R-HSA-194023.4
summation	[Summation:193973] Cortisol and NADP+ react to form cortisone, NADPH, and H+. T...
(hasEvent)	[Pathway:194002] Glucocorticoid biosynthesis [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9784289] Update Tracker - [Reaction:194023] HSD11B2,HSD11B1 dimer oxidise CORT to COR - v54:[modifyText] [_UpdateTracker:9784672] Update Tracker - [Reaction:194023] HSD11B2,HSD11B1 dimer oxidise CORT to COR - v53:[addLiteratureReference, modifyText]
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