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Details on Person CYP11B1 oxidises 11DCORT

Class:IdReaction:193997
_displayNameCYP11B1 oxidises 11DCORT
_doReleaseTRUE
_timestamp2024-08-02 16:57:24
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:193999] steroid 11-beta-monooxygenase activity of Cytochrome P450 (CYP11B1 based) [mitochondrial inner membrane]
compartment[Compartment:5460] mitochondrial matrix
[Compartment:70616] mitochondrial inner membrane
created[InstanceEdit:194008] Jassal, B, 2007-03-06 13:54:16
crossReference[DatabaseIdentifier:9907735] RHEA:46101
edited[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input[SimpleEntity:193998] 11DCORT [mitochondrial matrix]
[SimpleEntity:113600] NADPH [mitochondrial matrix]
[SimpleEntity:113600] NADPH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113533] O2 [mitochondrial matrix]
internalReviewed[InstanceEdit:9907738] D'Eustachio, Peter, 2024-04-15
literatureReference[LiteratureReference:194016] Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)
[LiteratureReference:194031] Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans
[LiteratureReference:1434477] A critical review of the origin and control of adrenal androgens
modified[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:211789] Jassal, Bijay, 2008-02-08
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:350840] Jassal, B, 2008-05-21 10:32:15
[InstanceEdit:351774] Jassal, B, 2008-05-28 08:42:08
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:1502543] Jassal, B, 2011-08-23
[InstanceEdit:5580323] Jassal, Bijay, 2014-06-10
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907736] D'Eustachio, Peter, 2024-04-15
[InstanceEdit:9907739] D'Eustachio, Peter, 2024-04-15
[InstanceEdit:9917358] D'Eustachio, Peter, 2024-08-02
nameCYP11B1 oxidises 11DCORT
11-deoxycortisol + 2 H(+) + O2 + 2 reduced (adrenodoxin) => cortisol + H2O + 2 oxidized (adrenodoxin)
11-deoxycortisol is oxidised to cortisol by CYP11B1
11-deoxycortisol + NADPH + H+ + O2 => cortisol + NADP+ + H2O
output[SimpleEntity:194011] CORT [mitochondrial matrix]
[SimpleEntity:113563] NADP+ [mitochondrial matrix]
[SimpleEntity:113563] NADP+ [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
regulatedBy[PositiveRegulation:1449717] Positive regulation by 'POMC(138-176) [cytosol]'
regulationReference[RegulationReference:9642949] Positive regulation by 'POMC(138-176) [cytosol]' Clinical review 104: Adrenocorticotropin (ACTH)- and non-ACTH-mediated regulation of the adrenal cortex: neural and immune inputs
releaseDate2007-05-15
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
[InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359133] R-HSA-193997.6
structureModified[InstanceEdit:9907736] D'Eustachio, Peter, 2024-04-15
summation[Summation:193986] Cytochrome P450 11B1, mitochondrial (CYP11B1) usually hydrox...
(hasEvent)[Pathway:194002] Glucocorticoid biosynthesis [Homo sapiens]
[Pathway:211976] Endogenous sterols [Homo sapiens]
(normalReaction)[FailedReaction:5580292] Defective CYP11B1 does not oxidise 11DCORT [Homo sapiens]
(precedingEvent)[BlackBoxEvent:194036] Cortisol translocates from the mitochondrial matrix to the cytosol [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786029] Update Tracker - [Reaction:193997] CYP11B1 oxidises 11DCORT - v50:[modifyText]
[_UpdateTracker:9789381] Update Tracker - [Reaction:193997] CYP11B1 oxidises 11DCORT - v38:[addLiteratureReference, addRegulator, modifyText]
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