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Details on Person CYP21A2 oxidises 17HPROG

Class:IdReaction:193981
_displayNameCYP21A2 oxidises 17HPROG
_doReleaseTRUE
_timestamp2025-09-23 18:22:18
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:194007] progesterone 21-hydroxylase activity of CYP21A2 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:194008] Jassal, B, 2007-03-06 13:54:16
crossReference[DatabaseIdentifier:9913420] RHEA:50309
edited[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input[SimpleEntity:193092] 17aHPROG [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol]
literatureReference[LiteratureReference:193989] Structure of human steroid 21-hydroxylase genes
[LiteratureReference:193990] Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia
modified[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5601985] Jassal, Bijay, 2014-06-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9913422] D'Eustachio, Peter, 2024-06-13
[InstanceEdit:9966633] D'Eustachio, Peter, 2025-09-23
nameCYP21A2 oxidises 17HPROG
17alpha-hydroxyprogesterone + O2 + reduced (NADPH--hemoprotein reductase) => 11-deoxycortisol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
Hydroxylation of 17-hydroxyprogesterone to form 11-deoxycortisol
17-hydroxyprogesterone + NADPH + H+ + O2 => 11-deoxycortisol + NADP+ + H2O
output[SimpleEntity:193966] 11-deoxycortisol [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29356] H2O [cytosol]
precedingEvent
releaseDate2007-05-15
reviewed[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358705] R-HSA-193981.4
summation[Summation:193992] 17-Hydroxyprogesterone, NADPH + H+, and O2 react to form 11-...
(hasEvent)[Pathway:194002] Glucocorticoid biosynthesis [Homo sapiens]
(precedingEvent)[BlackBoxEvent:194025] 11-deoxycortisol translocates to the mitochondrion [Homo sapiens]
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