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Details on Person CYP11B2 oxidises 18HCORST to ALDO

Class:IdReaction:193965
_displayNameCYP11B2 oxidises 18HCORST to ALDO
_doReleaseTRUE
_timestamp2024-08-02 16:57:36
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:193967] steroid hydroxylase activity of CYP11B2 [mitochondrial inner membrane]
compartment[Compartment:5460] mitochondrial matrix
[Compartment:70616] mitochondrial inner membrane
created[InstanceEdit:194008] Jassal, B, 2007-03-06 13:54:16
crossReference[DatabaseIdentifier:9907745] RHEA:50793
edited[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input[SimpleEntity:194012] 18HCORST [mitochondrial matrix]
[SimpleEntity:113600] NADPH [mitochondrial matrix]
[SimpleEntity:113600] NADPH [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113529] H+ [mitochondrial matrix]
[SimpleEntity:113533] O2 [mitochondrial matrix]
internalReviewed[InstanceEdit:9907183] D'Eustachio, Peter, 2024-04-04
[InstanceEdit:9907753] D'Eustachio, Peter, 2024-04-16
literatureReference[LiteratureReference:194016] Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)
[LiteratureReference:194015] Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism
modified[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:196338] D'Eustachio, P, 2007-04-20 18:44:40
[InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50
[InstanceEdit:196399] D'Eustachio, P, 2007-04-21 16:30:10
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:565782] D'Eustachio, P, 2010-04-08
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5600601] Jassal, Bijay, 2014-06-12
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907181] D'Eustachio, Peter, 2024-04-04
[InstanceEdit:9907182] D'Eustachio, Peter, 2024-04-04
[InstanceEdit:9907186] D'Eustachio, Peter, 2024-04-04
[InstanceEdit:9907746] D'Eustachio, Peter, 2024-04-16
[InstanceEdit:9907754] D'Eustachio, Peter, 2024-04-16
[InstanceEdit:9917358] D'Eustachio, Peter, 2024-08-02
nameCYP11B2 oxidises 18HCORST to ALDO
18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced (adrenodoxin) => aldosterone + 2 H2O + 2 oxidized (adrenodoxin)
18-hydroxycorticosterone + NADPH + H+ => aldosterone + NADP+ + 2H2O
output[SimpleEntity:193982] ALDO [mitochondrial matrix]
[SimpleEntity:113563] NADP+ [mitochondrial matrix]
[SimpleEntity:113563] NADP+ [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
[SimpleEntity:113521] H2O [mitochondrial matrix]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2007-05-15
reviewed[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
[InstanceEdit:9907185] Hill, David P, 2024-04-04
[InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:358543] R-HSA-193965.4
structureModified[InstanceEdit:9907181] D'Eustachio, Peter, 2024-04-04
[InstanceEdit:9907746] D'Eustachio, Peter, 2024-04-16
summation[Summation:196325] 18-Hydroxycorticosterone and NADPH + H+ react to form aldost...
(hasEvent)[Pathway:193993] Mineralocorticoid biosynthesis [Homo sapiens]
[Pathway:211976] Endogenous sterols [Homo sapiens]
(normalReaction)[FailedReaction:6785244] Defective CYP11B2 does not oxidise 18HCORST [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790500] Update Tracker - [Reaction:193965] CYP11B2 oxidises 18HCORST to ALDO - v33:[addInput]
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