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Query author contributions in Reactome

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Details on Person CYP21A2 21-hydroxylates PROG

Class:IdReaction:193964
_displayNameCYP21A2 21-hydroxylates PROG
_doReleaseTRUE
_timestamp2024-04-16 22:17:54
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:194007] progesterone 21-hydroxylase activity of CYP21A2 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:194008] Jassal, B, 2007-03-06 13:54:16
crossReference[DatabaseIdentifier:9907749] RHEA:50305
edited[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input[SimpleEntity:193055] P4 [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol]
literatureReference[LiteratureReference:193989] Structure of human steroid 21-hydroxylase genes
[LiteratureReference:193990] Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia
modified[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:196338] D'Eustachio, P, 2007-04-20 18:44:40
[InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:350840] Jassal, B, 2008-05-21 10:32:15
[InstanceEdit:351774] Jassal, B, 2008-05-28 08:42:08
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5601985] Jassal, Bijay, 2014-06-16
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907746] D'Eustachio, Peter, 2024-04-16
nameCYP21A2 21-hydroxylates PROG
O2 + progesterone + reduced (NADPH--hemoprotein reductase) => 21-hydroxyprogesterone + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
21-hydroxylation of progesterone to form 11-deoxycorticosterone
progesterone + NAPDH + H+ + O2 => 11-deoxycorticosterone + NADP+ + H2O
output[SimpleEntity:194037] 11DCORST [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29356] H2O [cytosol]
precedingEvent
releaseDate2007-05-15
reviewed[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359839] R-HSA-193964.3
summation[Summation:196348] Progesterone, NAPDH + H+, and O2 react to form 11-deoxycorti...
(hasEvent)[Pathway:193993] Mineralocorticoid biosynthesis [Homo sapiens]
[Pathway:211976] Endogenous sterols [Homo sapiens]
(normalReaction)[FailedReaction:5601976] Defective CYP21A2 does not 21-hydroxylate PROG [Homo sapiens]
(precedingEvent)[BlackBoxEvent:193996] 11DCORST translocates from cytosol to mitochondrial matrix [Homo sapiens]
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No pathways have been reviewed or authored by CYP21A2 21-hydroxylates PROG (193964)
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