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Details on Person SQSTM1 [cytosol]
Class:Id EntityWithAccessionedSequence:193937
_displayName SQSTM1 [cytosol]
_timestamp 2013-12-04 20:30:13
compartment [Compartment:70101] cytosol
created [InstanceEdit:193875] Jassal, B, 2007-03-01 15:14:39
endCoordinate 440
modified [InstanceEdit:352306] Jassal, B, 2008-06-02 09:53:24 [InstanceEdit:528073] Jassal, B, 2010-02-24 [InstanceEdit:3632907] Wu, G, 2013-05-28 [InstanceEdit:5205621] Gillespie, Marc E, 2013-12-04
name SQSTM1 p62 Sequestosome-1 SQSTM_HUMAN
referenceEntity [ReferenceGeneProduct:193910] UniProt:Q13501 SQSTM1 [Homo sapiens]
species [Species:48887] Homo sapiens
stableIdentifier [StableIdentifier:368433] R-HSA-193937.1
startCoordinate 1
(hasComponent) [Complex:193912] mature NGF:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] [Homo sapiens] [Complex:193917] mature NGF:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi:IKK-beta [plasma membrane] [Homo sapiens] [Complex:193940] mature NGF:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi:Phospho-IKK-beta [plasma membrane] [Homo sapiens] [Complex:193945] mature NGF:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] [Homo sapiens] [Complex:205035] Ubiquitinated NRIF:Sequestosome [cytosol] [Homo sapiens] [Complex:209542] NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] [Homo sapiens] [Complex:209565] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] [Homo sapiens] [Complex:209577] NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] [Homo sapiens] [Complex:507714] MAP3K3:SQSTM1 [cytosol] [Homo sapiens] [Complex:5205659] K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] [Homo sapiens]
(input) [Reaction:193694] p62 is recruited and forms a complex with TRAF6 [Homo sapiens] [Reaction:205008] Polyubiquitinated NRIF binds to p62 (Sequestosome) [Homo sapiens] [Reaction:5205673] p62 binds ubiquitinated mitochondrial substrates [Homo sapiens] [Reaction:9664892] SQSTM1 binds ATM dimer:Ub-p-PEX5 [Homo sapiens] [Reaction:9685004] SQSTM1 binds lipid droplet [Reaction:9685019] NBR1 and SQSTM1 bind ubiquitinated proteins in aggresome [Reaction:9687919] RNF166 ubiquitinates SQSTM1 [Homo sapiens] [Reaction:9687928] SQSTM1 binds p-OPTN:Ub-pathogen [Homo sapiens] [Reaction:9687930] SQSTM1 binds ubiquitinated pathogen [Homo sapiens] [Reaction:9759154] TRIM21 ubiquitinates SQSTM1 [Homo sapiens]
(output) [BlackBoxEvent:9759157] NFE2L2-dependent SQSTM1 gene expression [Homo sapiens]
(physicalEntity) [CatalystActivity:205028] ubiquitin binding activity of SQSTM1 [cytosol]
(updatedInstance) [_UpdateTracker:9869056] Update Tracker - [EntityWithAccessionedSequence:193937] SQSTM1 [cytosol] - v32:[addName]
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Pathways
No pathways have been reviewed or authored by SQSTM1 [cytosol] (193937)