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Details on Person Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one

Class:Id	Reaction:193789
_displayName	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one
_doRelease	TRUE
_timestamp	2026-04-27 21:30:34
authored	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
catalystActivity	[CatalystActivity:192106] steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of HSD3B7 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
crossReference	[DatabaseIdentifier:9987759] RHEA:47201
edited	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
input	[SimpleEntity:192189] CHOL7a,24(S)DIOL [endoplasmic reticulum membrane] [SimpleEntity:29360] NAD+ [cytosol]
literatureReference	[LiteratureReference:193374] Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease [LiteratureReference:193532] The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis
modified	[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27
name	Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (24S)-7alpha-dihydroxycholesterol + NAD(+) => (24S)-7alpha,24-dihydroxycholest-4-en-3-one + H(+) + NADH
output	[SimpleEntity:193724] 4CHOL7a,24(S)DONE [endoplasmic reticulum membrane] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:192178] CYP39A1 7-hydroxylates 24OH-CHOL [Homo sapiens] [BlackBoxEvent:193767] Influx of 24-hydroxycholesterol [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360488] R-HSA-193789.2
summation	[Summation:193744] Cholest-5-ene-3beta,7alpha,24(S)-triol and NAD+ react to for...
(hasEvent)	[Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol [Homo sapiens]
(precedingEvent)	[Reaction:193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL [Homo sapiens] [Reaction:193746] 4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one [Homo sapiens]
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No pathways have been reviewed or authored by Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one (193789)