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Details on Person 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al

Class:Id	Reaction:193780
_displayName	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al
_doRelease	FALSE
_timestamp	2026-04-28 21:56:10
authored	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
catalystActivity	[CatalystActivity:192037] oxidoreductase activity, acting on NAD(P)H as acceptor of CYP27A1 [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
edited	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
input	[SimpleEntity:193782] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol [mitochondrial matrix] [SimpleEntity:113533] O2 [mitochondrial matrix] [SimpleEntity:113600] NADPH [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
literatureReference	[LiteratureReference:192197] Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis. [LiteratureReference:193375] Activities of recombinant human cytochrome P450c27 (CYP27) which produce intermediates of alternative bile acid biosynthetic pathways
modified	[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9987887] D'Eustachio, Peter, 2026-04-28
name	5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol + NADPH + H+ + O2 => 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al + NADP+ + H2O
output	[SimpleEntity:193785] 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al [mitochondrial matrix] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:193787] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol [Homo sapiens] [Reaction:193774] 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is translocated from the cytosol to the mitochondrial matrix [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361807] R-HSA-193780.2
summation	[Summation:193756] 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol, NADPH...
(precedingEvent)	[Reaction:193713] 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA) [Homo sapiens]
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No pathways have been reviewed or authored by 5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al (193780)