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Details on Person Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoAw

Class:Id	Reaction:193763
_displayName	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoAw
_doRelease	FALSE
_timestamp	2026-04-28 21:56:17
authored	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
catalystActivity	[CatalystActivity:191973] racemase and epimerase activity of AMACR [peroxisomal matrix]
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
edited	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
input	[SimpleEntity:193793] 25(R) TetraHCA-CoA [peroxisomal matrix]
literatureReference	[LiteratureReference:192112] Purification and characterization of an alpha-methylacyl-CoA racemase from human liver [LiteratureReference:192185] Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans [LiteratureReference:193502] Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy
modified	[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9987887] D'Eustachio, Peter, 2026-04-28
name	Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoAw 25(R) TetraHCA-CoA => (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA
output	[SimpleEntity:193422] (24R, 25R) 3a,7a,12a,24-tetrahydroxy-5b-cholestanoyl-CoA [peroxisomal matrix]
precedingEvent	[Reaction:193761] 25(R) TetraHCA-CoA is translocated from the cytosol to the peroxisome [Homo sapiens] [Reaction:193727] TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS) [Homo sapiens] [Reaction:193766] TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360472] R-HSA-193763.2
summation	[Summation:193712] The isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alph...
(precedingEvent)	[Reaction:193455] (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA [Homo sapiens]
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