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Details on Person 3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)

Class:Id	Reaction:193711
_displayName	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)
_doRelease	TRUE
_timestamp	2008-06-20 09:42:24
authored	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
catalystActivity	[CatalystActivity:192026] long-chain fatty acid-CoA ligase activity of SLC27A5 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
edited	[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
input	[SimpleEntity:193778] 3,7,24THCA [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:76194] CoA-SH [cytosol]
literatureReference	[LiteratureReference:192044] Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein [LiteratureReference:191995] The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase [LiteratureReference:193432] Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling
modified	[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS) 3,7,24THCA + ATP + CoASH => 3,7,24THCA-CoA + AMP + pyrophosphate + H2O (SCLS25A5 "BACS")
output	[SimpleEntity:193739] 3,7,24THCA-CoA [cytosol] [SimpleEntity:76577] AMP [cytosol] [SimpleEntity:111294] PPi [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[BlackBoxEvent:193786] 3,7,24THCA is translocated from the mitochondrial matrix to the cytosol [Homo sapiens] [Reaction:193737] 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA) [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360377] R-HSA-193711.2
summation	[Summation:193726] 3,7,24THCA (25(R) 3alpha,7alpha,24(S)-trihydroxy-5beta-chole...
(hasEvent)	[Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol [Homo sapiens]
(precedingEvent)	[Reaction:193753] 3,7,24THCA-CoA is translocated from the cytosol to the peroxisome [Homo sapiens]
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