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Details on Person CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL

Class:IdReaction:193709
_displayNameCYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL
_doReleaseFALSE
_timestamp2026-04-28 21:56:14
authored[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity[CatalystActivity:192125] sterol 12-alpha-hydroxylase activity of CYP8B1 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
edited[InstanceEdit:193783] D'Eustachio, P, 2007-02-23 20:35:09
input[SimpleEntity:193724] 4CHOL7a,24(S)DONE [endoplasmic reticulum membrane]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
[SimpleEntity:29368] O2 [cytosol]
literatureReference[LiteratureReference:192101] Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns
[LiteratureReference:5602286] Purification and characterization of 7 alpha-hydroxy-4-cholesten-3-one 12 alpha-hydroxylase
modified[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:350661] Jassal, Bijay, 2008-05-20
[InstanceEdit:351776] Jassal, Bijay, 2008-05-28
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5602279] Jassal, Bijay, 2014-06-23
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9907727] D'Eustachio, Peter, 2024-04-15
[InstanceEdit:9910727] D'Eustachio, Peter, 2024-05-17
[InstanceEdit:9987887] D'Eustachio, Peter, 2026-04-28
nameCYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL
4-Cholesten-7alpha,24(S)-diol-3-one is 12alpha-hydroxylated to 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one
4-Cholesten-7alpha,24(S)-diol-3-one + NADPH + H+ + O2 => 4-cholesten-7-alpha,12-alpha,24(S)-triol-3-one + NADP+ + H2O
output[SimpleEntity:193745] 4CHOL7a,12a,24(S)TONE [endoplasmic reticulum membrane]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29356] H2O [cytosol]
precedingEvent
releaseDate2007-05-15
reviewed[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
reviewStatus[ReviewStatus:9821382] five stars
revised[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361467] R-HSA-193709.3
summation[Summation:193738] Sterol 12alpha hydroxylase (CYP8B1) catalyses the 12-alpha-h...
(hasEvent)[Pathway:211994] Sterols are 12-hydroxylated by CYP8B1 [Homo sapiens]
(precedingEvent)[Reaction:193755] 4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786340] Update Tracker - [Reaction:193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL - v50:[addLiteratureReference, modifyText]
[_UpdateTracker:9910982] Update Tracker - [Reaction:193709] CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL - v89:[modifyText]
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No pathways have been reviewed or authored by CYP8B1 12-hydroxylates 4CHOL7a,24(S)DIOL (193709)
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