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Details on Person (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA

Class:IdReaction:193508
_displayName(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
_doReleaseTRUE
_timestamp2026-04-27 21:30:16
authored[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity[CatalystActivity:193365] oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of HSD17B4 dimer [peroxisomal matrix]
compartment[Compartment:17951] peroxisomal matrix
created[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
crossReference[DatabaseIdentifier:9987753] RHEA:47405
edited[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
input[SimpleEntity:193732] 3,7,24THCA-CoA [peroxisomal matrix]
[SimpleEntity:192307] NAD+ [peroxisomal matrix]
literatureReference[LiteratureReference:192311] Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase
modified[InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08
[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:9032308] D'Eustachio, Peter, 2017-12-09
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27
name(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA
(24R,25R)-3alpha,7alpha,24-trihydroxy-5beta-cholestan-26-oyl-CoA + NAD(+) => 3alpha,7alpha-dihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + H(+) + NADH
output[SimpleEntity:193403] 3a,7a-dihydroxy-5b-cholest-24-one-CoA [peroxisomal matrix]
[SimpleEntity:192305] NADH [peroxisomal matrix]
[SimpleEntity:193465] H+ [peroxisomal matrix]
precedingEvent
releaseDate2007-05-15
reviewed[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:360549] R-HSA-193508.3
summation[Summation:193411] (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-Co...
(hasEvent)[Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Homo sapiens]
(precedingEvent)[Reaction:193533] Thiolysis of 3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA yields chenodeoxycholoyl-CoA (3alpha,7alpha-dihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9779963] Update Tracker - [Reaction:193508] (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA - v64:[add_removeInput]
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