Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person 25(R) DHCA-CoA is translocated from the cytosol to the peroxisome

Class:IdReaction:193482
_displayName25(R) DHCA-CoA is translocated from the cytosol to the peroxisome
_doReleaseTRUE
_timestamp2026-04-23 19:20:49
authored[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity[CatalystActivity:9987431] ATPase-coupled transmembrane transporter activity of ABCD3 dimer [peroxisomal membrane]
catalystActivityReference[CatalystActivityReference:9987430] ATPase-coupled transmembrane transporter activity of ABCD3 dimer [peroxisomal membrane] A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3
compartment[Compartment:17947] peroxisomal membrane
created[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
edited[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
goBiologicalProcess[GO_BiologicalProcess:25870] peroxisomal membrane transport
input[SimpleEntity:193457] 25(R) DHCA-CoA [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:29356] H2O [cytosol]
internalReviewed[InstanceEdit:9987449] D'Eustachio, Peter, 2026-04-15
literatureReference[LiteratureReference:9987436] A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3
[LiteratureReference:9987441] Live cell FRET microscopy: homo- and heterodimerization of two human peroxisomal ABC transporters, the adrenoleukodystrophy protein (ALDP, ABCD1) and PMP70 (ABCD3)
[LiteratureReference:192080] The enzymes, regulation, and genetics of bile acid synthesis
[LiteratureReference:193419] ATP-dependent transport of bile acid intermediates across rat liver peroxisomal membranes
modified[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:198215] D'Eustachio, P, 2007-05-26 19:03:08
[InstanceEdit:843134] Matthews, L, 2010-05-28
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9961097] D'Eustachio, Peter, 2025-07-18
[InstanceEdit:9987445] D'Eustachio, Peter, 2026-04-15
[InstanceEdit:9987448] D'Eustachio, Peter, 2026-04-15
[InstanceEdit:9987670] D'Eustachio, Peter, 2026-04-23
name25(R) DHCA-CoA is translocated from the cytosol to the peroxisome
25(R) DHCA-CoA [ cytosol] => 25(R) DHCA-CoA [peroxisome]
output[SimpleEntity:193429] 25(R) DHCA-CoA [peroxisomal matrix]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29372] Pi [cytosol]
[SimpleEntity:70106] H+ [cytosol]
precedingEvent
previousReviewStatus[ReviewStatus:9821385] four stars
releaseDate2007-05-15
reviewed[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
[InstanceEdit:9987671] Hill, David P, 2026-04-23
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359631] R-HSA-193482.3
structureModified[InstanceEdit:9987445] D'Eustachio, Peter, 2026-04-15
summation[Summation:193507] 25(R) DHCA-CoA is transported from the cytosol into the pero...
(hasEvent)[Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Homo sapiens]
(precedingEvent)[Reaction:193452] Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA [Homo sapiens]
(updatedInstance)[_UpdateTracker:9792265] Update Tracker - [Reaction:193482] 25(R) DHCA-CoA is translocated from the cytosol to the peroxisome - v22:[addLiteratureReference]
[Change default viewing format]
No pathways have been reviewed or authored by 25(R) DHCA-CoA is translocated from the cytosol to the peroxisome (193482)
Follow Reactome