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Details on Person THCA is conjugated with Coenzyme A (SLC27A2 VLCS)

Class:IdReaction:193401
_displayNameTHCA is conjugated with Coenzyme A (SLC27A2 VLCS)
_doReleaseTRUE
_timestamp2026-04-27 21:30:42
authored[InstanceEdit:191331] Jassal, Bijay, 2007-01-19
catalystActivity[CatalystActivity:193506] long-chain fatty acid-CoA ligase activity of SLC27A2 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
crossReference[DatabaseIdentifier:9987760] RHEA:22977
edited[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
input[SimpleEntity:192013] THCA [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:76194] CoA-SH [cytosol]
literatureReference[LiteratureReference:192044] Human liver-specific very-long-chain acyl-coenzyme A synthetase: cDNA cloning and characterization of a second enzymatically active protein
[LiteratureReference:191995] The human liver-specific homolog of very long-chain acyl-CoA synthetase is cholate:CoA ligase
[LiteratureReference:193432] Participation of two members of the very long-chain acyl-CoA synthetase family in bile acid synthesis and recycling
modified[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16
[InstanceEdit:564713] D'Eustachio, P, 2010-04-05
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27
nameTHCA is conjugated with Coenzyme A (SLC27A2 VLCS)
(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA => (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate
THCA + ATP + CoASH => 25(R) THCA-CoA + AMP + pyrophosphate (SLC27A2 "VLCS")
output[SimpleEntity:192096] 25(R) THCA-CoA [cytosol]
[SimpleEntity:76577] AMP [cytosol]
[SimpleEntity:111294] PPi [cytosol]
precedingEvent
releaseDate2007-05-15
reviewed[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359433] R-HSA-193401.2
summation[Summation:193413] THCA (25(R) 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan...
(hasEvent)[Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Homo sapiens]
(precedingEvent)[Reaction:192325] 25(R) THCA-CoA is translocated from the cytosol to the peroxisome [Homo sapiens]
(updatedInstance)[_UpdateTracker:9790535] Update Tracker - [Reaction:193401] THCA is conjugated with Coenzyme A (SLC27A2 VLCS) - v33:[modifyText, removeOutput]
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