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Details on Person A molecule of glycocholate, glycochenodeoxycholate, taurocho...

Class:IdSummation:193394
_displayNameA molecule of glycocholate, glycochenodeoxycholate, taurocho...
_timestamp2007-03-09 21:33:35
created[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
literatureReference[LiteratureReference:193474] Enterohepatic bile salt transporters in normal physiology and liver disease
[LiteratureReference:193414] Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis
modified[InstanceEdit:194078] D'Eustachio, P, 2007-03-08 15:03:08
[InstanceEdit:194163] D'Eustachio, P, 2007-03-09 21:33:16
textA molecule of glycocholate, glycochenodeoxycholate, taurocholate, or taurochenodeoxycholate is transported from the cytosol to the extracellular space, coupled to the hydrolysis of a molecule of cytosolic ATP to ADP and orthophosphate. This reaction is mediated by ABCB11 (bile salt export pump). In the body, this reaction mediates the release of bile salts from the liver cells into the bile (Kullak-Ublick et al. 2004); the role of ABCB11 in the reaction is confirmed by the observed failure of bile salt export in patients in whom the transporter is defective (Noe et al. 2005).
(summation)[Reaction:193362] ABCB11 transports bile salts from cytosol to extracellular region [Homo sapiens]
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