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Details on Person ABCB11 transports bile salts from cytosol to extracellular region

Class:Id	Reaction:193362
_displayName	ABCB11 transports bile salts from cytosol to extracellular region
_doRelease	TRUE
_timestamp	2026-04-27 21:34:52
authored	[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
catalystActivity	[CatalystActivity:193367] ABC-type bile acid transporter activity of ABCB11 [plasma membrane]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33
crossReference	[DatabaseIdentifier:9987741] RHEA:50056 [DatabaseIdentifier:9987758] RHEA:50060 [DatabaseIdentifier:9987740] RHEA:50052 [DatabaseIdentifier:9987747] RHEA:50064
edited	[InstanceEdit:193475] D'Eustachio, P, 2007-02-17 19:40:28
input	[DefinedSet:193416] bile salts [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:29356] H2O [cytosol]
internalReviewed	[InstanceEdit:9987781] D'Eustachio, Peter, 2026-04-27
literatureReference	[LiteratureReference:193526] Functional expression of the canalicular bile salt export pump of human liver [LiteratureReference:193518] The human bile salt export pump: characterization of substrate specificity and identification of inhibitors
modified	[InstanceEdit:194078] D'Eustachio, P, 2007-03-08 15:03:08 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16 [InstanceEdit:211336] D'Eustachio, P, 2008-01-31 21:19:00 [InstanceEdit:975967] Jassal, Bijay, 2010-10-11 [InstanceEdit:5678752] Jassal, Bijay, 2015-02-26 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27 [InstanceEdit:9987782] D'Eustachio, Peter, 2026-04-27
name	ABCB11 transports bile salts from cytosol to extracellular region ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate ATP + glycochenodeoxycholate(in) + H2O = ADP + glycochenodeoxycholate(out) + H(+) + phosphate ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out) ATP + H2O + taurochenodeoxycholate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate(out)
output	[DefinedSet:193479] bile salts [extracellular region] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29372] Pi [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[BlackBoxEvent:192315] Bile salts are translocated from the peroxisomal matrix to the cytosol [Homo sapiens] [Reaction:192312] Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate [Homo sapiens] [Reaction:193491] Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate [Homo sapiens] [Reaction:194121] SLC10A1 co-transport bile salts and Na+ from extracellular region to cytosol [Homo sapiens] [Reaction:194153] ABCC3 transports bile salts from cytosol to extracellular region [Homo sapiens] [BlackBoxEvent:9733545] Bile salts and acids bind ALB [Homo sapiens] [Reaction:194130] Transport (influx) of bile salts and acids by OATP-A [Homo sapiens] [Reaction:194153] ABCC3 transports bile salts from cytosol to extracellular region [Homo sapiens] [Reaction:194079] SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol [Homo sapiens] [Reaction:194153] ABCC3 transports bile salts from cytosol to extracellular region [Homo sapiens] [Reaction:194083] SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol [Homo sapiens] [Reaction:194153] ABCC3 transports bile salts from cytosol to extracellular region [Homo sapiens] [Reaction:159431] Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine [Homo sapiens] [Reaction:159425] Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS) [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2007-05-15
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus	[ReviewStatus:9821385] four stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358377] R-HSA-193362.2
structureModified	[InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27
summation	[Summation:193394] A molecule of glycocholate, glycochenodeoxycholate, taurocho...
(hasEvent)	[Pathway:159418] Recycling of bile acids and salts [Homo sapiens] [Pathway:193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol [Homo sapiens]
(normalReaction)	[FailedReaction:5678517] Defective ABCB11 does not transport bile salts from cytosol to extracellular region [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790177] Update Tracker - [Reaction:193362] ABCB11 transports bile salts from cytosol to extracellular region - v35:[addInput]
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