Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person CHOL (cholesterol) traverses the cytosol and the mitochondri...
| Class:Id | Summation:193130 |
|---|---|
| _displayName | CHOL (cholesterol) traverses the cytosol and the mitochondri... |
| _timestamp | 2025-06-06 21:07:23 |
| created | [InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33 |
| literatureReference | [LiteratureReference:196065] The pathophysiology and genetics of congenital lipoid adrenal hyperplasia. International Congenital Lipoid Adrenal Hyperplasia Consortium. [LiteratureReference:196072] StAR search--what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol import [LiteratureReference:196112] The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6 [LiteratureReference:196061] StAR protein and the regulation of steroid hormone biosynthesis [LiteratureReference:8873819] MLN64 and MENTHO, two mediators of endosomal cholesterol transport |
| modified | [InstanceEdit:196115] D'Eustachio, P, 2007-04-17 18:04:28 [InstanceEdit:8873825] Jassal, Bijay, 2016-05-20 [InstanceEdit:8877145] Jassal, Bijay, 2016-06-21 [InstanceEdit:9954144] D'Eustachio, Peter, 2025-06-06 |
| text | CHOL (cholesterol) traverses the cytosol and the mitochondrial intermembrane space complexed with STARD cholesterol-binding proteins. A plausible model, supported by studies in vitro and in cells overexpressing cloned human proteins, is that cytosolic STARD proteins bind cholesterol liberated from lysosomes or cytosolic lipid droplets and carry it to the outer mitochondrial membrane (Rodriguez-Aguado et al. 2005; Soccio et al. 2002), where STAR steroidogenic acute regulatory protein mediates its delivery to the mitochondrial inner membrane (Miller 2007, Letourneau et al. 2015). This process is essential for steroid hormone synthesis. Mutations in the gene encoding STAR block synthesis of all steroid hormones in humans (Bose et al. 1996). The transport step is also a key site for normal regulation of steroid hormone synthesis, as STAR protein is unstable and its synthesis is up-regulated in response to signals such as the binding of ACTH to its receptors on adrenal cells (Stocco 2001). |
| (summation) | [Reaction:196126] STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space [Homo sapiens] |
| [Change default viewing format] | |
