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Details on Person CYP17A1 cleaves 17aHPROG to ANDST

Class:IdReaction:193099
_displayNameCYP17A1 cleaves 17aHPROG to ANDST
_doReleaseTRUE
_timestamp2025-09-23 18:22:14
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:193113] steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
edited[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input[SimpleEntity:193092] 17aHPROG [cytosol]
[SimpleEntity:29368] O2 [cytosol]
[SimpleEntity:29364] NADPH [cytosol]
[SimpleEntity:70106] H+ [cytosol]
literatureReference[LiteratureReference:193045] Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations
modified[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:196132] D'Eustachio, P, 2007-04-17 18:12:49
[InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50
[InstanceEdit:196399] D'Eustachio, P, 2007-04-21 16:30:10
[InstanceEdit:197126] Gopinathrao, G, 2007-04-30 17:36:12
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:5601814] Jassal, Bijay, 2014-06-13
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9966633] D'Eustachio, Peter, 2025-09-23
nameCYP17A1 cleaves 17aHPROG to ANDST
Side chain cleavage of 17alpha-hydroxyprogesterone to form 4-Androstene-3, 17-dione
17alpha-hydroxyprogesterone + NADPH + H+ + O2 => 4-Androstene-3, 17-dione + NADP+ + H2O + acetaldehyde
negativePrecedingEvent[NegativePrecedingEvent:9966635] Different Cell Type: Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone
output[SimpleEntity:193079] ANDST [cytosol]
[SimpleEntity:29366] NADP+ [cytosol]
[SimpleEntity:29356] H2O [cytosol]
[SimpleEntity:29510] CH3CHO [cytosol]
precedingEvent
releaseDate2007-05-15
reviewed[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:359887] R-HSA-193099.3
summation[Summation:196391] 17Alpha-hydroxyprogesterone (17aHPROG), NADPH + H+, and O2 r...
(hasEvent)[Pathway:193048] Androgen biosynthesis [Homo sapiens]
(normalReaction)[FailedReaction:9035956] Defective CYP17A1 does not cleave 17aHPROG [Homo sapiens]
(precedingEvent)[Reaction:193060] CYP19A1 hydroxylates ANDST to E1 [Homo sapiens]
[Reaction:193064] HSD17B3-like proteins reducde ANDST to TEST [Homo sapiens]
[Reaction:9705925] Androgens binds AR (in the HSP90 chaperone complex) [Homo sapiens]
(updatedInstance)[_UpdateTracker:9786131] Update Tracker - [Reaction:193099] CYP17A1 cleaves 17aHPROG to ANDST - v50:[modifyText]
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No pathways have been reviewed or authored by CYP17A1 cleaves 17aHPROG to ANDST (193099)
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