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Details on Person HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST

Class:Id	Reaction:193073
_displayName	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST
_doRelease	TRUE
_timestamp	2020-10-29 12:03:10
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193169] steroid Delta-isomerase activity of HSD3B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input	[SimpleEntity:29360] NAD+ [cytosol] [SimpleEntity:176626] DHEA [cytosol]
literatureReference	[LiteratureReference:192183] Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells [LiteratureReference:1434477] A critical review of the origin and control of adrenal androgens
modified	[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:196132] D'Eustachio, P, 2007-04-17 18:12:49 [InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50 [InstanceEdit:196399] D'Eustachio, P, 2007-04-21 16:30:10 [InstanceEdit:197126] Gopinathrao, G, 2007-04-30 17:36:12 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1502543] Jassal, B, 2011-08-23 [InstanceEdit:1606810] Jassal, B, 2011-09-27 [InstanceEdit:1609660] Jassal, B, 2011-09-27 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9705709] Jassal, Bijay, 2020-10-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST DHA isomerizes to 4-Androstene3,17-dione
output	[SimpleEntity:193079] ANDST [cytosol] [SimpleEntity:73473] NADH [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:193070] CYP17A1 cleaves 17aHPREG to DHA [Homo sapiens] [Reaction:193068] CYP17A1 17-hydroxylates PREG [Homo sapiens]
regulatedBy	[PositiveRegulation:1449719] Positive regulation by 'POMC(138-176) [cytosol]'
regulationReference	[RegulationReference:9642807] Positive regulation by 'POMC(138-176) [cytosol]' A critical review of the origin and control of adrenal androgens
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358805] R-HSA-193073.5
summation	[Summation:193085] In this two-step reaction catalyzed by 3beta-HSD associated ...
(hasEvent)	[Pathway:193048] Androgen biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:193060] CYP19A1 hydroxylates ANDST to E1 [Homo sapiens] [Reaction:193064] HSD17B3-like proteins reducde ANDST to TEST [Homo sapiens] [Reaction:9705925] Androgens binds AR (in the HSP90 chaperone complex) [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9788961] Update Tracker - [Reaction:193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST - v39:[add_removeInput] [_UpdateTracker:9789400] Update Tracker - [Reaction:193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST - v38:[addLiteratureReference, addRegulator, modifyText]
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