Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person CYP17A1 17-hydroxylates P4 to 17aHPROG

Class:Id	Reaction:193072
_displayName	CYP17A1 17-hydroxylates P4 to 17aHPROG
_doRelease	TRUE
_timestamp	2020-10-29 12:02:42
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193113] steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input	[SimpleEntity:193055] P4 [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:193045] Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations
modified	[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:196132] D'Eustachio, P, 2007-04-17 18:12:49 [InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50 [InstanceEdit:196399] D'Eustachio, P, 2007-04-21 16:30:10 [InstanceEdit:197126] Gopinathrao, G, 2007-04-30 17:36:12 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:5601814] Jassal, Bijay, 2014-06-13 [InstanceEdit:9705709] Jassal, Bijay, 2020-10-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CYP17A1 17-hydroxylates P4 to 17aHPROG Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone progesterone + NADPH + H+ + O2 => 17alpha-hydroxyprogesterone + NADP+ + H2O
output	[SimpleEntity:193092] 17aHPROG [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol]
precedingEvent	[Reaction:193052] Pregn-5-ene-3,20-dione isomerizes to progesterone [Homo sapiens] [Reaction:196350] Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:359816] R-HSA-193072.3
summation	[Summation:193067] Progesterone (P4), NADPH + H+, and O2 react to form 17alpha-...
(hasEvent)	[Pathway:193048] Androgen biosynthesis [Homo sapiens]
(normalReaction)	[FailedReaction:9035954] Defective CYP17A1 does not 17-hydroxylate P4 [Homo sapiens]
(precedingEvent)	[Reaction:193099] CYP17A1 cleaves 17aHPROG to ANDST [Homo sapiens] [Reaction:193981] CYP21A2 oxidises 17HPROG [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786263] Update Tracker - [Reaction:193072] CYP17A1 17-hydroxylates P4 to 17aHPROG - v50:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by CYP17A1 17-hydroxylates P4 to 17aHPROG (193072)