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Details on Person CYP17A1 cleaves 17aHPREG to DHA

Class:Id	Reaction:193070
_displayName	CYP17A1 cleaves 17aHPREG to DHA
_doRelease	TRUE
_timestamp	2020-10-29 12:02:50
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193113] steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input	[SimpleEntity:193124] 17aHPREG [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:193045] Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations [LiteratureReference:1434477] A critical review of the origin and control of adrenal androgens
modified	[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:196132] D'Eustachio, P, 2007-04-17 18:12:49 [InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50 [InstanceEdit:196399] D'Eustachio, P, 2007-04-21 16:30:10 [InstanceEdit:197126] Gopinathrao, G, 2007-04-30 17:36:12 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:469649] Jassal, B, 2010-01-25 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:1502543] Jassal, B, 2011-08-23 [InstanceEdit:1606810] Jassal, B, 2011-09-27 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9705709] Jassal, Bijay, 2020-10-29 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CYP17A1 cleaves 17aHPREG to DHA Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA 17alpha-hydroxyprenenolone + NADPH + H+ + O2 => DHA (dehydroepiandrostenedione) + NADP+ + H2O + acetaldehyde
output	[SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29510] CH3CHO [cytosol] [SimpleEntity:176626] DHEA [cytosol]
precedingEvent	[Reaction:193068] CYP17A1 17-hydroxylates PREG [Homo sapiens] [BlackBoxEvent:193097] Pregnenolone translocates from the mitochondrial matrix to the cytosol [Homo sapiens]
regulatedBy	[PositiveRegulation:1449712] Positive regulation by 'POMC(138-176) [cytosol]'
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:361000] R-HSA-193070.4
summation	[Summation:193146] 17-alpha-hydroxypregnenolone, NADPH + H+, and O2 react to fo...
(hasEvent)	[Pathway:193048] Androgen biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789067] Update Tracker - [Reaction:193070] CYP17A1 cleaves 17aHPREG to DHA - v39:[add_removeOutput] [_UpdateTracker:9789504] Update Tracker - [Reaction:193070] CYP17A1 cleaves 17aHPREG to DHA - v38:[addLiteratureReference, addRegulator, modifyText]
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