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Details on Person CYP17A1 17-hydroxylates PREG

Class:Id	Reaction:193068
_displayName	CYP17A1 17-hydroxylates PREG
_doRelease	TRUE
_timestamp	2024-06-13 20:24:36
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193113] steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
crossReference	[DatabaseIdentifier:9913419] RHEA:50237
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input	[SimpleEntity:193103] PREG [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol]
literatureReference	[LiteratureReference:193045] Molecular modeling of human P450c17 (17alpha-hydroxylase/17,20-lyase): insights into reaction mechanisms and effects of mutations
modified	[InstanceEdit:194039] Jassal, B, 2007-03-06 13:57:31 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:196057] D'Eustachio, P, 2007-04-17 17:56:03 [InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197126] Gopinathrao, G, 2007-04-30 17:36:12 [InstanceEdit:350661] Jassal, Bijay, 2008-05-20 [InstanceEdit:350849] Jassal, B, 2008-05-21 10:36:56 [InstanceEdit:351780] Jassal, B, 2008-05-28 09:06:10 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:5601814] Jassal, Bijay, 2014-06-13 [InstanceEdit:5602279] Jassal, Bijay, 2014-06-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9913422] D'Eustachio, Peter, 2024-06-13
name	CYP17A1 17-hydroxylates PREG O2 + pregnenolone + reduced (NADPH--hemoprotein reductase) => 17alpha-hydroxypregnenolone + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) Hydroxylation of pregnenolone to form 17alpha-hydroxypregnenolone pregnenolone + NADPH + H+ => 17alpha-hydroxypregnenolone + NADP+ + H2O
output	[SimpleEntity:193124] 17aHPREG [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol]
precedingEvent	[BlackBoxEvent:193097] Pregnenolone translocates from the mitochondrial matrix to the cytosol [Homo sapiens] [Reaction:193101] CYP11A1 cleaves 20a,22b-DHCHOL [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358988] R-HSA-193068.3
summation	[Summation:193077] Pregnenolone (PREG) and NADPH + H+ react to form 17alpha-hyd...
(hasEvent)	[Pathway:193048] Androgen biosynthesis [Homo sapiens] [Pathway:194002] Glucocorticoid biosynthesis [Homo sapiens]
(normalReaction)	[FailedReaction:5601843] Defective CYP17A1 does not 17-hydroxylate PREG [Homo sapiens]
(precedingEvent)	[Reaction:193070] CYP17A1 cleaves 17aHPREG to DHA [Homo sapiens] [Reaction:196372] 17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786318] Update Tracker - [Reaction:193068] CYP17A1 17-hydroxylates PREG - v50:[modifyText]
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No pathways have been reviewed or authored by CYP17A1 17-hydroxylates PREG (193068)