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Details on Person Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol

Class:Id	Reaction:193065
_displayName	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol
_doRelease	TRUE
_timestamp	2008-11-17 10:24:20
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193154] cholesterol monooxygenase (side-chain-cleaving) activity of CYP11A1:FDXR:FDX1,FDX1L (red.) [mitochondrial matrix]
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input	[SimpleEntity:193019] 22b-HCHOL [mitochondrial inner membrane] [SimpleEntity:113600] NADPH [mitochondrial matrix] [SimpleEntity:113533] O2 [mitochondrial matrix] [SimpleEntity:113529] H+ [mitochondrial matrix]
literatureReference	[LiteratureReference:193118] Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta [LiteratureReference:193076] Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462
modified	[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:196338] D'Eustachio, P, 2007-04-20 18:44:40 [InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol 22beta-hydroxycholesterol + NADPH + H+ + O2 => 20alpha,22beta-hydroxycholesterol + NADP+ + H2O
output	[SimpleEntity:193086] 20a,22b-DHCHOL [mitochondrial inner membrane] [SimpleEntity:113521] H2O [mitochondrial matrix] [SimpleEntity:113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:193054] Oxidation of cholesterol to 22beta-hydroxycholesterol [Homo sapiens] [Reaction:8951850] TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane [Homo sapiens] [Reaction:196126] STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space [Homo sapiens]
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360321] R-HSA-193065.2
summation	[Summation:193050] 22beta-hydroxycholesterol, NADPH + H+, and O2 react to form ...
(hasEvent)	[Pathway:196108] Pregnenolone biosynthesis [Homo sapiens]
(precedingEvent)	[Reaction:193101] CYP11A1 cleaves 20a,22b-DHCHOL [Homo sapiens]
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