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Details on Person CYP19A1 hydroxylates ANDST to E1

Class:Id	Reaction:193060
_displayName	CYP19A1 hydroxylates ANDST to E1
_doRelease	TRUE
_timestamp	2025-09-23 18:22:17
authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:193170] steroid hydroxylase activity of CYP19A1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
crossReference	[DatabaseIdentifier:9907748] RHEA:38196
edited	[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input	[SimpleEntity:193079] ANDST [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:29364] NADPH [cytosol] [SimpleEntity:29364] NADPH [cytosol]
internalReviewed	[InstanceEdit:9907753] D'Eustachio, Peter, 2024-04-16
literatureReference	[LiteratureReference:193081] Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis [LiteratureReference:193115] Structural and functional characterization of human aromatase P-450 gene
modified	[InstanceEdit:193224] Jassal, B, 2007-02-13 13:58:49 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:196132] D'Eustachio, P, 2007-04-17 18:12:49 [InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50 [InstanceEdit:196399] D'Eustachio, P, 2007-04-21 16:30:10 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:211789] Jassal, Bijay, 2008-02-08 [InstanceEdit:350661] Jassal, Bijay, 2008-05-20 [InstanceEdit:350840] Jassal, B, 2008-05-21 10:32:15 [InstanceEdit:351780] Jassal, B, 2008-05-28 09:06:10 [InstanceEdit:380824] Jassal, Bijay, 2008-11-17 [InstanceEdit:555951] D'Eustachio, P, 2010-03-22 [InstanceEdit:560557] D'Eustachio, P, 2010-03-24 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:5601814] Jassal, Bijay, 2014-06-13 [InstanceEdit:5602279] Jassal, Bijay, 2014-06-23 [InstanceEdit:6782166] Jassal, Bijay, 2015-06-05 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9907746] D'Eustachio, Peter, 2024-04-16 [InstanceEdit:9907754] D'Eustachio, Peter, 2024-04-16 [InstanceEdit:9917358] D'Eustachio, Peter, 2024-08-02 [InstanceEdit:9966633] D'Eustachio, Peter, 2025-09-23
name	CYP19A1 hydroxylates ANDST to E1 Androstenedione is converted to estrone by Aromatase (CYP19A1) androst-4-ene-3,17-dione + 3 O2 + 3 reduced (NADPH--hemoprotein reductase) => estrone + formate + 4 H(+) + 4 H2O + 3 oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:193066] E1 [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29460] HCOOH [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:29366] NADP+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[Reaction:193099] CYP17A1 cleaves 17aHPROG to ANDST [Homo sapiens] [Reaction:193072] CYP17A1 17-hydroxylates P4 to 17aHPROG [Homo sapiens] [Reaction:193073] HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST [Homo sapiens] [Reaction:193070] CYP17A1 cleaves 17aHPREG to DHA [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2007-05-15
reviewed	[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21 [InstanceEdit:9917333] Hill, David P, 2024-08-02
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:358801] R-HSA-193060.6
structureModified	[InstanceEdit:9907746] D'Eustachio, Peter, 2024-04-16
summation	[Summation:196396] The conversion of androstenedione (ANDST) to estrone (E1) is...
(hasEvent)	[Pathway:193144] Estrogen biosynthesis [Homo sapiens] [Pathway:211976] Endogenous sterols [Homo sapiens]
(normalReaction)	[FailedReaction:5601849] Defective CYP19A1 does not convert ANDST to E1 [Homo sapiens]
(precedingEvent)	[Reaction:804969] HSD17B1 hydrogenates E1 to EST17b [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9786216] Update Tracker - [Reaction:193060] CYP19A1 hydroxylates ANDST to E1 - v50:[modifyText] [_UpdateTracker:9910983] Update Tracker - [Reaction:193060] CYP19A1 hydroxylates ANDST to E1 - v89:[addOutput]
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