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Details on Person Pregn-5-ene-3,20-dione isomerizes to progesterone

Class:IdReaction:193052
_displayNamePregn-5-ene-3,20-dione isomerizes to progesterone
_doReleaseTRUE
_timestamp2008-11-17 10:24:49
authored[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity[CatalystActivity:193169] steroid Delta-isomerase activity of HSD3B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]
compartment[Compartment:70101] cytosol
[Compartment:12045] endoplasmic reticulum membrane
created[InstanceEdit:193053] Jassal, B, 2007-02-13 10:16:33
edited[InstanceEdit:196368] Jassal, B, 2007-04-20 21:09:56
input[SimpleEntity:196344] pregn-5-ene-3,20-dione [cytosol]
literatureReference[LiteratureReference:192183] Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells
[LiteratureReference:196332] Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes
[LiteratureReference:196346] Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads
[LiteratureReference:196356] Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase
modified[InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22
[InstanceEdit:196338] D'Eustachio, P, 2007-04-20 18:44:40
[InstanceEdit:196365] D'Eustachio, P, 2007-04-20 21:30:50
[InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02
[InstanceEdit:380824] Jassal, Bijay, 2008-11-17
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namePregn-5-ene-3,20-dione isomerizes to progesterone
output[SimpleEntity:193055] P4 [cytosol]
precedingEvent
regulatedBy[PositiveRegulation:1449722] Positive regulation by 'glyco-Lutropin [extracellular region]'
releaseDate2007-05-15
reviewed[InstanceEdit:196370] D'Eustachio, P, 2007-04-20 21:11:21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:361980] R-HSA-193052.3
summation[Summation:193122] Pregn-5-ene-3,20-dione isomerizes to progesterone. This reac...
(hasEvent)[Pathway:193993] Mineralocorticoid biosynthesis [Homo sapiens]
(precedingEvent)[Reaction:193072] CYP17A1 17-hydroxylates P4 to 17aHPROG [Homo sapiens]
[Reaction:193964] CYP21A2 21-hydroxylates PROG [Homo sapiens]
(updatedInstance)[_UpdateTracker:9789370] Update Tracker - [Reaction:193052] Pregn-5-ene-3,20-dione isomerizes to progesterone - v38:[addRegulator, modifyText]
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