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Details on Person The viral polymerase complex produces positive-sense viral m...

Class:IdSummation:192673
_displayNameThe viral polymerase complex produces positive-sense viral m...
_timestamp2007-11-13 15:33:14
created[InstanceEdit:192697] Gillespie, ME, 2007-02-07 04:51:41
literatureReference[LiteratureReference:192628] Polyuridylated mRNA synthesized by a recombinant influenza virus is defective in nuclear export
[LiteratureReference:192714] Association of the influenza A virus RNA-dependent RNA polymerase with cellular RNA polymerase II
modified[InstanceEdit:197159] Gillespie, ME, 2007-04-30 20:06:36
[InstanceEdit:203491] Gillespie, ME, 2007-11-13 15:31:51
textThe viral polymerase complex produces positive-sense viral mRNA with host-cell derived 5' methyl caps. Capped viral mRNAs are selectively exported from the host cell nucleus through a currently unclear mechanism that may rely on components of the host cell mRNA export machinery (Chen, 2000; Engelhardt, 2006). Polyadenylation of viral mRNA appears be required for influenza mRNA export (Poon, 2000). A coupling of viral mRNA export with cellular pre-mRNA processing complexes, recruited by phosphorylation of host RNA polymerase II C-terminal domain which interacts with the viral polymerase (Engelhardt, 2005), has been proposed as controlling the export of a subset (M1, HA, and NS1, but not NP) of viral mRNA from the nucleus (Amorim, 2007).
(summation)[Reaction:192627] Viral mRNA Export [Homo sapiens]
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