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Details on Person UniProt:Q96RS0 TGS1
| Class:Id | ReferenceGeneProduct:192207 |
|---|---|
| _chainChangeLog | chain:1-853 added on Sat February 7 2015 |
| _displayName | UniProt:Q96RS0 TGS1 |
| _timestamp | 2025-02-21 19:13:30 |
| chain | chain:1-853 |
| checksum | FF670AFBE0979443 |
| comment | FUNCTION Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation.CATALYTIC ACTIVITY a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)CATALYTIC ACTIVITY a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 8.5-9.5.SUBUNIT May form homooligomers. Interacts with CREBBP/CBP, EED/WAIT1, EP300/P300, NCOA6/PRIP, PPARBP/PBP and SMN.INTERACTION A 90 kDa isoform is found in the nucleus while a 55 kDa isoform is found in the cytoplasm and colocalizes with the tubulin network.TISSUE SPECIFICITY Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta.SIMILARITY Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:192208] Gillespie, ME, 2007-01-29 18:19:14 |
| description | recommendedName: Trimethylguanosine synthase ecNumber evidence="11"2.1.1.- alternativeName: CLL-associated antigen KW-2 alternativeName: Cap-specific guanine-N(2) methyltransferase alternativeName: Hepatocellular carcinoma-associated antigen 137 alternativeName: Nuclear receptor coactivator 6-interacting protein alternativeName: PRIP-interacting protein with methyltransferase motif shortName: PIMT shortName: PIPMT |
| geneName | TGS1 HCA137 NCOA6IP PIMT |
| identifier | Q96RS0 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Methyltransferase Nucleus Phosphoprotein Proteomics identification Reference proteome S-adenosyl-L-methionine Transcription Transcription regulation Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | TGS1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992784] ENSEMBL:ENSG00000137574 TGS1 [Homo sapiens] |
| secondaryIdentifier | TGS1_HUMAN A6NJQ5 Q5GH23 Q8TDG9 Q96QU3 Q9H5V3 |
| sequenceLength | 853 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:192209] TGS1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:400176] TGS1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96RS0 TGS1 (192207)
