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Details on Person Sakai, J

Class:Id	Person:192179
_displayName	Sakai, J
_timestamp	2007-01-26 15:42:09
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
initial	J
surname	Sakai
(author)	[LiteratureReference:192168] cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism [LiteratureReference:1655558] Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment [LiteratureReference:1655572] Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies [LiteratureReference:1655593] Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein [LiteratureReference:1655599] Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells [LiteratureReference:1655646] Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
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No pathways have been reviewed or authored by Sakai, J (192179)