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Details on Person CYP39A1 7-hydroxylates 24OH-CHOL

Class:Id	Reaction:192178
_displayName	CYP39A1 7-hydroxylates 24OH-CHOL
_doRelease	TRUE
_timestamp	2026-04-27 21:34:54
authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:192129] oxysterol 7-alpha-hydroxylase activity of CYP39A1 [endoplasmic reticulum membrane]
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:191989] Jassal, Bijay, 2007-01-26
crossReference	[DatabaseIdentifier:9907750] RHEA:46125
edited	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
input	[SimpleEntity:192060] 24OH-CHOL [endoplasmic reticulum membrane] [SimpleEntity:29368] O2 [cytosol] [SimpleEntity:1131953] hydrogen donor [cytosol]
internalReviewed	[InstanceEdit:9987781] D'Eustachio, Peter, 2026-04-27
literatureReference	[LiteratureReference:191969] Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol
modified	[InstanceEdit:192930] Gopinathrao, G, 2007-02-07 12:39:47 [InstanceEdit:193586] D'Eustachio, P, 2007-02-21 16:52:00 [InstanceEdit:193768] D'Eustachio, P, 2007-02-23 20:48:08 [InstanceEdit:195718] Gopinathrao, G, 2007-04-16 17:35:22 [InstanceEdit:197014] Gopinathrao, G, 2007-04-30 12:01:02 [InstanceEdit:197116] D'Eustachio, P, 2007-04-30 14:50:16 [InstanceEdit:350661] Jassal, Bijay, 2008-05-20 [InstanceEdit:351774] Jassal, B, 2008-05-28 08:42:08 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:5602279] Jassal, Bijay, 2014-06-23 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9907746] D'Eustachio, Peter, 2024-04-16 [InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27 [InstanceEdit:9987782] D'Eustachio, Peter, 2026-04-27
name	CYP39A1 7-hydroxylates 24OH-CHOL (24S)-hydroxycholesterol + O2 + reduced (NADPH--hemoprotein reductase) => (24S)-7alpha-dihydroxycholesterol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase) 24-hydroxycholesterol is 7alpha-hydroxylated to yield cholest-5-ene-3beta,7alpha,24-triol 24-hydroxycholesterol + NADPH + H+ + O2 => cholest-5-ene-3beta,7alpha,24-triol + NADP+ + H2O
output	[SimpleEntity:192189] CHOL7a,24(S)DIOL [endoplasmic reticulum membrane] [SimpleEntity:29356] H2O [cytosol] [SimpleEntity:1130886] hydrogen acceptor [cytosol] [SimpleEntity:70106] H+ [cytosol]
precedingEvent	[BlackBoxEvent:193767] Influx of 24-hydroxycholesterol [Homo sapiens] [BlackBoxEvent:193776] Efflux of 24-hydroxycholesterol [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2007-05-15
reviewed	[InstanceEdit:197117] D'Eustachio, P, 2007-04-30 14:43:26
reviewStatus	[ReviewStatus:9821385] four stars
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:360262] R-HSA-192178.3
structureModified	[InstanceEdit:9987742] D'Eustachio, Peter, 2026-04-27
summation	[Summation:192109] 24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1), located...
(hasEvent)	[Pathway:193775] Synthesis of bile acids and bile salts via 24-hydroxycholesterol [Homo sapiens] [Pathway:211976] Endogenous sterols [Homo sapiens]
(precedingEvent)	[Reaction:193789] Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785999] Update Tracker - [Reaction:192178] CYP39A1 7-hydroxylates 24OH-CHOL - v50:[modifyText]
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No pathways have been reviewed or authored by CYP39A1 7-hydroxylates 24OH-CHOL (192178)