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Details on Person Cholesterol, NADPH + H+, and O2 form 7alpha-cholesterol (5-c...
| Class:Id | Summation:192159 |
|---|---|
| _displayName | Cholesterol, NADPH + H+, and O2 form 7alpha-cholesterol (5-c... |
| _timestamp | 2014-06-23 14:49:16 |
| created | [InstanceEdit:191989] Jassal, Bijay, 2007-01-26 |
| literatureReference | [LiteratureReference:193477] Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype [LiteratureReference:192080] The enzymes, regulation, and genetics of bile acid synthesis |
| modified | [InstanceEdit:193476] D'Eustachio, P, 2007-02-19 17:36:33 [InstanceEdit:5602279] Jassal, Bijay, 2014-06-23 |
| text | Cholesterol, NADPH + H+, and O2 form 7alpha-cholesterol (5-cholesten-3beta, 7alpha-diol), NADP+,and H2O, in a reaction catalysed by CYP7A1 (cholesterol 7alpha-hydroylase) in the endoplasmic reticulum membrane. In the body, this enzyme is expressed only in liver, and its expression is tightly regulated at the level of transcription to determine the overall rate of bile acid and bile salt production (Noshiro et al. 1990). |
| (summation) | [Reaction:192051] CYP7A1 7-hydroxylates CHOL [Homo sapiens] |
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No pathways have been reviewed or authored by Cholesterol, NADPH + H+, and O2 form 7alpha-cholesterol (5-c... (192159)
